中国肺癌杂志2018，Vol.21Issue(2)：121-128,8.DOI:10.3779/j.issn.1009-3419.2018.02.06
长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展
Advances in Long Non-coding RNAs on Resistant to EGFR-TKIs in Non-small Cell Lung Cancer
摘要
Abstract
Most non-small cell lung cancer patients with active epidermal growth factor receptor(EGFR)muta-tion will eventually acquire drug resistant to EGFR tyrosine kinase inhibitors, such as gefitinib, resulting in disease progression, which involves a variety of complex mechanisms. Up to now, the molecular mechanisms of long non-coding RNAs mediated EGFR-TKIs resistance remains poorly understood. This review aims to outline the current state of information on lncRNAs and progress on its role in EGFR-TKIs resistance in non-small cell lung cancer.关键词
肺肿瘤/EGFR-TKIs/耐药/长链非编码RNAKey words
Lung neoplasms/Epidermal growth factor receptor-tyrosine kinase inhibitors/Resistance/Long non-coding RNA引用本文复制引用
李树斌,于鸿,张耿月..长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展[J].中国肺癌杂志,2018,21(2):121-128,8.基金项目
本研究受吉林省卫生技术创新项目(No.2017J025)资助 This paper was supported by the grant from the Health Technology Innovation Project of Jilin Province(to Hong YU)(No.2017J025). （No.2017J025）
