局解手术学杂志2017，Vol.26Issue(11)：831-833,3.DOI:10.11659/jjssx.08E017075
含铋剂四联疗法10 d和14 d疗程对幽门螺杆菌根除疗效的研究
Eradication of bismuth-containing quadruple therapy on helicobacter pylori for 10 days and 14 days
王涛 1廖忠莉 1杨丽 1程姮 1郭红1
作者信息
- 1. 第三军大学新桥医院消化内科,重庆400037
- 折叠
摘要
Abstract
Objective To compare the efficacy of bismuth-containing quadruple therapy on H.pylori eradication for 10 days versus 14 days in a randomized controlled trial.Methods A total of 240 patients diagnosed with H.pylori infection were randomly assigned to two groups:treated with esomeprazole,bismuth,clarithromycin and amoxicillin for 10 days(n =117) and for 14 days (n =123).Eradication was defined by rapid urease test or 13C-urea breath test at 4 weeks after drug withdrawal.Results A total of 219 patients were complete the trial.Intention-to-treat(ITT) analysis showed that the eradication rate of 10 and 14 days were 77.8％ (91/117)and 76.4％ (94/123)respectively.Per protocol(PP) analysis indicated that the eradication rate of 10 and 14 days were 85.8％ (91/106) and 83.2％ (94/113) respectively.There was no statistically significant differences between the two groups(P ＞ 0.05).The incidence of adverse events were 7.7％ (9/117)and 9.8％ (12/123),respectively.There was no significant difference (P ＞ 0.05).Conclusion The eradication rate of bismuth-containing quadruple therapy for 10 days and 14 days were essentially identical,bismuth-containing quadruple therapy for 10 days has a higher potency ratio.关键词
幽门螺杆菌/含铋剂四联疗法/根除率Key words
helicobacter pylori/bismuth-containing quadruple therapy/eradication rate分类
医药卫生引用本文复制引用
王涛,廖忠莉,杨丽,程姮,郭红..含铋剂四联疗法10 d和14 d疗程对幽门螺杆菌根除疗效的研究[J].局解手术学杂志,2017,26(11):831-833,3.
