局解手术学杂志2018，Vol.27Issue(2)：88-92,5.DOI:10.11659/jjssx.07E017081
自体富血小板血浆凝胶联合皮瓣移植修复对难愈性创面的治疗效果
Clinical effect of platelet-rich plasma combined with flap transplantation in treatment of refractory wounds
摘要
Abstract
Objective To investigate the clinical effect of platelet-rich plasma combined with flap transplantation in treatment of refractory wounds.Methods Sixty patients of refractory wounds who were admitted into our hospital from April 2016 to February 2017 were enrolled in the observation group,and another sixty patients with refractory wounds who had been discharged from the hospital before April 2016 were trea-ted as the control group.All the patients accepted debridement and disinfection.Then the observation group were managed with PRP and flap transplantation,while the control group were treated with flap transplantation directly without PRP.Observed the frequency of dressing changes, rate of wound infection,healing time and recovering rate of the two groups.Measurement data were analyzed with t inspection and analysis of va-riance,and count data were compared by χ2test,and repeat data was analyzed with repeat data variance analysis.Results After one weeks' treatment,the number of wet gauze layers were(20.5 ±1.6)in the observation group,which was less than(23.3 ±6.1)in the control group with statistically significant difference(t=-3.439,P=0.001).The healing time of the observation group was(25 ±2)d,which was shorter than(43 ±5)d in the control group(t=-25.891,P=0.000).The frequency of dressing changes was(7.1 ±1.0)times in observation group, which was less than(9.3 ±1.4)times in the control group(t=-9.905,P=0.000).There were 5 cases of inflammation reaction in the obser-vation group,which was less than 18 cases in the control group(χ2=9.090,P=0.003).The cases of the skin flap survival in the observation group was 55,which was more than 41 cases in the control group,and the difference of the two groups was statistically significant(χ2=10.208, P=0.001).The average healing rate of the two groups both increased at different time points.And the average healing rate of the observation group was higher than that in the control group at different time points,and the difference was statistically significant(P<0.05).Conclusion Platelet-rich plasma can remarkably shorten the healing time,improve healing rate,reduce frequency of dressing change and promote wound healing for refractory wound.关键词
富血小板血浆/PRP/难愈性创面/皮瓣移植Key words
platelet-rich plasma/PRP/refractory wound/flap transplantation分类
医药卫生引用本文复制引用
高文华,张宏亮,胡玉庆,樊安末,刘景焕,刘学亮..自体富血小板血浆凝胶联合皮瓣移植修复对难愈性创面的治疗效果[J].局解手术学杂志,2018,27(2):88-92,5.基金项目
邢台市科技支撑计划课题(2017zc050) （2017zc050）
