中国临床医学2017，Vol.24Issue(5)：705-709,5.DOI:10.12025/j.issn.1008-6358.2017.20170037
血液透析患者脂代谢现况调查及影响因素分析
Investigation of lipid metabolism disorder in maintenance hemodialysis patients and its influencing factors
摘要
Abstract
Objective:To investigate the lipid levels of maintenance hemodialysis (MHD) patients from single center and to explore the related risk factors.Methods:MHD patients (dialysis duration ＞3 months) in blood purification center of Zhongshan Hospital,Fudan University were enrolled in the research.Fasting blood lipid including triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C),glycosylated hemoglobin (HbA1c),serum albumin and other indicators were tested,and dialysis adequacy evaluation was made.At the same time,patients' general information and medical history were collected.Results:The average levels of TC,TG,HDL-C and LDL-C in 203 patients were (4.45 ± 1.16) mmol/L,(1.93 ± 2.18) mmol/L,(1.16 ± 0.34) mmol/L,(2.51 ± 0.93) mmol/L,respectively.132 patients (65％) were bothered by lipid abnormalities.Proportions of serum high TC and LDL-C abnormality were higher in women than in men while low HDL-C abnormality proportion was lower in women than in men (P＜0.05).Serum TG level was higher in patients over 60 years old than those under 45 years old and among 45-59 years old (P＜0.05).However,patients under 45 years old had the highest prevalence of dyslipidemia (P＜0.05).Patients with dialysis duration ＞60 months had lower proportion of TG abnormality than patients with duration ＜12 months and among 12 60 months (P＜0.05).Prevalence of dyslipidemia was highest in the group with duration ＜12 months (P＜0.05).Serum TG level was lower in patients with HbA1c≤6％ than in patients with HbA1c＞6％ (P＜O.05). Higher prevalence of dyslipidemia occurred in patients with HbA1c＞6％ (P＜O.05).Conclusions: Lipid metabolism disorder is common among MHD patients.Female, dialysis duration＜12 months, younger than 45years old, and HbA1c＞6% are risk factors of lipid metabolism abnormality in such patients.关键词
血液透析/脂质代谢/横断面研究/危险因素Key words
hemodialysis/lipid metabolism/cross-sectional study/risk factors分类
医药卫生引用本文复制引用
王莉,高健,沈波,丁小强,吕文律,曹学森,刘中华,滕杰,邹建洲..血液透析患者脂代谢现况调查及影响因素分析[J].中国临床医学,2017,24(5):705-709,5.基金项目
国家重点研发计划项目(2016YFC1305500),上海市进一步加快中医药事业发展三年行动计划(2014 ZY3-CCCX-3-3043).Supported by the State Key Research&Development Program(2016YFC1305500) and Plans to Further Accelerate the Development of Traditional Chinese Medicine for Three Years in Shanghai (2014 ZY3-CCCX-3-3043). （2016YFC1305500）
