中国临床医学2017，Vol.24Issue(5)：710-714,5.DOI:10.12025/j.issn.1008-6358.2017.20170361
呼出气一氧化氮水平对变应性哮喘的诊断价值
The diagnostic value of fractional exhaled nitric oxide in allergic asthma
摘要
Abstract
Objective:To evaluate the diagnostic value of fractional exhaled nitric oxide (FeNO) in allergic asthma.Methods:A total of 147 cases of asthma patients who were newly diagnosed or non-standardly treated in the Respiratory Department of Zhongshan Hospital Affiliated to Fudan University from August 2015 to September 2016 were enrolled.The patients were divided into allergic asthma group (n =107) and non-allergic asthma group (n =40).Before standardized treatment,FeNO,lung function,and serum total IgE tests were performed.The receiver operating characteristic curve (ROC) was made to evaluate the diagnostic value of FeNO in allergic asthma.Results:The values of FeNO and total serum IgE were significantly higher in allergic asthma group than those in non-allergic asthma group (P＜0.05),but there was no statistical difference between these two groups in FEV1 ％ pred,FEV1/FVC,or FVC％ pred.In allergic asthma group,the FeNO level was positively correlated with serum total IgE (r=0.298,P＜0.001),but had no correlation with FEV1 ％pred,FEV1/FVC,or FVC％pred.There was no correlation between FeNO and serum total IgE,FEV1 ％,FEV1/FVC,or FVC％ in non-allergic asthma group.In allergic asthma group,there was no statistical difference in FeNO levels between positive and negative patients in the bronchial dilation test.The cut-off value of FeNO to differentiate allergic asthma was 40.05 ppb (1 ppb =1 μL/m3) according to the ROC curve (AUC 0.971,sensitivity 96.3％,specificity 85.0％).Conclusions:FeNO is significantly increased in newly diagnosed or non-standard treatment of allergic asthma and has positive correlation with serum total IgE.When the FeNO value is above 40.05 ppb,the diagnosis of allergic asthma is highly likely.关键词
呼出气一氧化氮/变应性哮喘/诊断价值Key words
fractional exhaled nitric oxide/allergic asthma/diagnostic value分类
医药卫生引用本文复制引用
韦素兰,王坚,牟艳,杨延杰,金美玲,朱蕾,叶伶..呼出气一氧化氮水平对变应性哮喘的诊断价值[J].中国临床医学,2017,24(5):710-714,5.基金项目
科技部国家重点研发计划(2016YFC1304002),上海市自然科学基金(16ZR1405700).Supported by Grants of the National R&D Program (2016YFC1304002) and Shanghai Natural Science Foundation (16ZR1405700). （2016YFC1304002）
