中国临床医学2017，Vol.24Issue(5)：715-718,4.DOI:10.12025/j.issn.1008-6358.2017.20170368
盐酸氟西汀联合重复经颅磁刺激治疗伴焦虑症状抑郁症的随机对照研究
A randomized controlled trial on fluoxetine combined with repetitive transcranial magnetic stimulation versus fluoxetine alone in the treatment of major depressive disorder with anxiety symptoms
摘要
Abstract
Objective:To compare the efficacy and safety of fluoxetine alone or fluoxetine hydrochloride combined with repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive disorder (MDD) with anxiety symptoms.Methods:One hundred and two inpatients diagnosed as MDD with anxiety symptoms were randomly divided into the combination group (rTMS plus fluoxetine,51 patients) and the control group (fluoxetine only,51 patients).The course of treatment was 8 weeks.Hamilton anxiety scale (HAMA),Hamilton depression scale (HAMD) and the treatment emergent symptoms scale (TESS) were used to evaluate the efficacy and side effects at baseline,2,4 and 8 weeks after treatment.Results:The total effective rate,HAMA and HAMD main effects of time and between groups,and the TESS score of the combined treatment group were better than those of the control group,and the differences were statistically significant (P＜ 0.05).Conclusions:The efficacy and safety of fluoxetine hydrochloride combined with rTMS are better in the treatment of depression with anxiety symptoms than those of fluoxetine alone.关键词
盐酸氟西汀/重复经颅磁刺激/抑郁症/焦虑症状Key words
fluoxetine/repetitive transcranial magnetic stimulation/major depressive disorder/anxiety分类
医药卫生引用本文复制引用
周平,张瑶,谭庆荣..盐酸氟西汀联合重复经颅磁刺激治疗伴焦虑症状抑郁症的随机对照研究[J].中国临床医学,2017,24(5):715-718,4.基金项目
国家自然科学基金(30870886).Supported by National Natural Science Foundation of China(30870886). （30870886）
