中国免疫学杂志2018，Vol.34Issue(1)：117-121,126,6.DOI:10.3969/j.issn.1000-484X.2018.01.023
F-actin重构对树突状细胞形态和功能影响的研究进展
Research progress on effects of F-actin remodeling on dendritic cell morphology and function
摘要
Abstract
Dendritic cells (DCs)are the most potent antigen presenting cells,which play crucial roles in initiating and amplifying both the innate and adaptive immune responses.In DCs' whole life,the dynamics of cytoskeleton is involved in the regulation of their deformation,migration,adhesion,endocytosis and antigen presentation.The cytoskeleton is a complex system and regulated by lots of cytoskeletal proteins.With the research going,our understanding on cytoskeleton system is getting clear.Based on these,we summarized the effects of filamentous actin (F-actin)cytoskeleton remodeling on the morphology and immune functions of DCs.关键词
树突状细胞/细胞骨架/纤维状肌动蛋白/形态/抗原提呈/迁移Key words
Dendritic cells/Cytoskeleton/Filamentous actin/Morphology/Antigen presenting/Migration分类
医药卫生引用本文复制引用
刘鲜梅,曾柱,姚伟娟..F-actin重构对树突状细胞形态和功能影响的研究进展[J].中国免疫学杂志,2018,34(1):117-121,126,6.基金项目
本文受国家自然科学基金(31570938,31660258,31260227,11162003)、中国博士后科学基金(2015M582758XB)、教育部科学技术基金重点项目(210196)、贵州省树突状细胞基础与应用开发科技创新人才团队(黔科合人才团队(2015)4021)和贵州省2011协同创新计划(黔教合协同创新字[2015]04)等项目支持. （31570938,31660258,31260227,11162003）
