中国实用妇科与产科杂志2018，Vol.34Issue(2)：160-164,5.DOI:10.19538/j.fk2018020110
未足月胎膜早破抗生素使用
Application of antibiotics in PPROM
孙笑 1时春艳1
作者信息
- 1. 北京大学第一医院妇产科,北京100034
- 折叠
摘要
Abstract
The causes of PPROM are multifactorial,but infection is the primary cause.Infection appears to either as a cause or as a consequence of PROM.Application of antibiotics in PPROM can reduce the morbidity rate and prolong the duration of pregnancy.After the diagnosis of PPROM,it is necessary to screen B streptococcus carriage of the vagina and perianal region and perform culture of midstream urine,and use broad spectrum antibiotics at the same time for those who expect to prevent miscarriage.The antibiotic regimen consists of 48 hours of intravenous therapy followed by five days of oral medications with a combination of ampicillin and erythromycin.It may be reasonable to administer erythromycin alone for women who are allergic to ampicillin.For positive group B streptococcus carriage or penicillin allergens appropriate antibiotics should be used.The benefit is greater at earlier gestational ages (＜ 32 weeks).Induction is recommended at later gestational ages (＞ 34 weeks).The use of antibiotics is according to individual circumstances.Women with PPROM and positive group B streptococcus carriage should receive intrapartum GBS prophylaxis to prevent vertical transmission regardless of earlier treatments.For those seriously infected,the use of broad-spectrum antibiotics should be used.关键词
早产/未足月胎膜早破/抗生素Key words
preterm birth/preterm premature rupture of membrane/antibiotics分类
医药卫生引用本文复制引用
孙笑,时春艳..未足月胎膜早破抗生素使用[J].中国实用妇科与产科杂志,2018,34(2):160-164,5.
