中国兽医科学2018，Vol.48Issue(2)：247-255,9.DOI:10.16656/j.issn.1673-4696.2018.0038
青蒿浸膏对昆明小鼠和Wistar大鼠的急性毒性试验
Acute toxicity tests of the extract from Artemisia annua in KM mice and Wistar rat
摘要
Abstract
The extract containing artemisinin from Artemisia annua L.can improve the growth performance of animal and immune functions,also resist against chicken coccidiosis and kill ciliate.So these extract have a wide range of application prospects in the animal husbandry industry.However,the toxicity effect of the extract remains unclear.In order to evaluate the toxicity of the extract,using the Bliss method,the LD50 and its 95％confidence of this extract(Artemisinin content:170 mg/kg±10 mg/kg) in Kunming mice and Wistar rat were determined after single oral administration within 7 days.In result,the mice from different dose group did not appear toxic symptoms,even these mice had normal locomotoractivity,feeding and water intake.There was no obvious difference between males and females on weight,after being exposed to this extract.But in Kunming mice,the effects of toxicity in rat were gradually inreased in a dose-dependent manner,in the group of 4 120 mg/kg just reduced locomotor activity,and the 6 460mg/kg,8 080 mg/kg and 10 100 mg/kg treatment groups with the extract displayed the symptoms of individual tremor,compulsion clonic convulsion and death.The LD50 was 7 360 mg/kg,and the 95％confidence limit was from 6 256.38 to 8 658.82 mg/kg in rat.In summary,the extract from Artemisia annua is nontoxic substance with nontoxicity in Kunming mice and Wistar rat.关键词
青蒿浸膏/急性毒性/昆明小鼠/Wistar大鼠Key words
extract from Artemisia annua/acute toxicity/Kunming mice/Wistar rat分类
农业科技引用本文复制引用
南旭梅,张敬,金小雪,肇昊驰,于鹏..青蒿浸膏对昆明小鼠和Wistar大鼠的急性毒性试验[J].中国兽医科学,2018,48(2):247-255,9.基金项目
国家自然科学基金项目(81660589) （81660589）
西北师范大学青年教师科研能力提升计划项目(NWNU-LKQN-13-8) （NWNU-LKQN-13-8）
