中国兽医科学2018，Vol.48Issue(2)：256-261,6.DOI:10.16656/j.issn.1673-4696.2018.0039
α-硫辛酸对亚慢性镉暴露致大鼠大脑皮质超微结构损伤的保护效应
Protective effects of α-lipoic acid on ultrastructure damage by sub-chronic cadmium exposure in cerebral cortex of rats
摘要
Abstract
In order to investigate the protective effects of α-lipoic acid(α-LA) on ultrastructure damage by sub-chronic cadmium(Cd) exposure in cerebral cortex of rats,twenty-four 21-day-old female SD rats were divided into 4 groups randomly:control group,α-LA group,Cd-treated group,Cd and α-LA co-treated group.The rats of Cd-treated group were exposed to Cd(50 mg/L) in drinking water,and α-LA(50 mg/kg) was given to rats by gavage at the same time in the co-treated group.After 12 weeks,the mass concentration of Cd in cerebral cortex was measured by atomic absorption spectrophotometer,the changes in ultrastructure of the cerebral cortex were observed under transmission electron microscope and the expression of apoptosis related protein was measured by Western-blot.The results showed that compared with Cd group,α-LA could decrease the mass concentration of Cd in cerebral cortex significantly(P＜ 0.05),relieve the ultrastructural damage,and inhibit the decline of Bcl-2/Bax ratio and the increase of protein expression of cleaved caspase-9 and-3 caused by Cd significantly(P＜0.05 or P＜0.01).The results indicated that α-LA could protect the ultrastructure damage by sub-chronic cadmium exposure in cerebral cortex of rats.关键词
亚慢性/镉/α-硫辛酸/SD大鼠/超微结构/大脑皮质Key words
sub-chronic/cadmium/α-lipoic acid/SD rat/ultrastructure/cerebral cortex分类
农业科技引用本文复制引用
赵世文,袁燕,杨金龙,陈洁,王涛,邹辉,顾建红,刘学忠,卞建春,刘宗平..α-硫辛酸对亚慢性镉暴露致大鼠大脑皮质超微结构损伤的保护效应[J].中国兽医科学,2018,48(2):256-261,6.基金项目
国家重点研发计划项目(2016YFD0501208) （2016YFD0501208）
江苏高校优势学科建设工程资助项目(PAPD) （PAPD）
国家自然科学基金资助项目(31772808) （31772808）
中国博士后科学基金资助项目(2015M581874) （2015M581874）
江苏省博士后科研资助计划项目(1501072A) （1501072A）
