中国实用口腔科杂志2018，Vol.11Issue(1)：44-47,4.DOI:10.19538/j.kq.2018.01.009
类风湿关节炎患者龈下菌斑精氨酸脱亚胺酶活性研究
Investigation of arginine deiminase activity of subgingival plaque in patients with rheumatoid arthritis
摘要
Abstract
Objective To investigate the role of arginine deiminase (ADI)in the correlation between rheumatoid arthritis (RA) and chronic periodontitis through examining the activities of ADI from subgingival plaque of patients with RA.Methods In this study,case-control study was adopted.From Jan.2014 to Dec.2016,thirty-four RA patients were recruited from Department of Rheumatology at the Fourth Affiliated Hospital of China Medical University.Twenty-nine healthy volunteers (without arthritis)were recruited as controls,who meat the inclusion criteria and had no arthritis symptoms or spinal disease history.ADI activities were tested by diacetylmonoxime-thiosemicarbazide colorimetry.Antibodies to cyclic citrullinated peptides (anti-CCP)in serum were tested by ELISA.Plaque index (PI),probing depth (PD),attachment loss (AL)and the number of missing teeth were examined for each participant.The independent-samples t test was used to compare the periodontal index and ADI.For anti-CCP,x2 analysis was used to compare the positive proportions.Results PI was 3.03 ± 1.97 in RA group and 3.52 ± 0.92 in control group(P ＞ 0.05).PD was(2.52 ± 0.89)mm in RA group and(2.63 ± 0.45)mm in control group (P ＞ 0.05).AL was (1.41 ±1.21)mm in RA group and(0.40 ± 0.33) mm in control group (P ＜ 0.01).The number of losing teeth was 4.29 ± 5.85 and 0.56 ± 0.80 in RA group and in control group,respectively (P ＜ 0.05).The activity of ADI was(1.59 ± 1.05)IU in RA group,significantly higher than (0.68 ± 1.08)IU in control group (t =3.38,P ＜ 0.01).The positive proportion of antiCCP antibody (≥ 20 RU/mL)was 55.9％ in RA group and 0 in control group(x2 =21.91,P ＜ 0.01).Conclusion The periodontal health is poorer and the activity of ADI in subgingival plaque is higher in patients with RA.It indicates that higher activity of ADI in subgingival plaque plays a key role in the correlation between RA and chronic periodontitis.关键词
类风湿关节炎/慢性牙周炎/龈下菌斑/精氨酸脱亚胺酶Key words
rheumatoid arthritis/chronic periodontitis/subgingival plaque/arginine deiminase分类
医药卫生引用本文复制引用
王绍峰,赵欣欣,刘海杰,崔有辰,毕莹..类风湿关节炎患者龈下菌斑精氨酸脱亚胺酶活性研究[J].中国实用口腔科杂志,2018,11(1):44-47,4.基金项目
辽宁省教育厅科学研究一般项目(L2013288) （L2013288）
