中国实用口腔科杂志2018，Vol.11Issue(1)：48-51,4.DOI:10.19538/j.kq.2018.01.010
口腔扁平苔藓及口腔鳞癌患者口腔黏膜组织中微小RNA-590表达研究
Expression of miR-590 in the oral tissues of patients with oral lichen planus and oral squamous carcinoma
吴岩 1田宏伟 1杜美仪1
作者信息
- 1. 锦州市口腔医院VIP科,辽宁锦州121000
- 折叠
摘要
Abstract
Objective To investigate the expression of miR-590 in the tissues of patients with oral lichen planus and oral squamous carcinoma and study its role in the carcinogenesis of oral mucosal cells.Methods Twenty female and twelve male OLP patients (OLP group)and seventeen female and eleven male OSCC patients (OSCC group)were selected,who were pathologically diagnosed in Jinzhou Stomatological Hospital from March 2014 to December 2015.Twenty healthy matched volunteers served as control group.The expressions of miR-590 in oral tissues of the three groups were examined by realtime PCR.The difference among the three groups was statistically analyzed.Results The relative expressions of miR-590 were significantly higher in OLP (1.96 ± 0.52)and OSCC patients (2.75 ± 0.78)than those in the healthy controls (0.77 ± 0.34)(P ＜ 0.05).There were significant differences in the expression of miR-590 between the OLP group and OSCC group(P ＜ 0.05).Conclusion The expressions of miR-590 are higher in OLP and OSCC patients than those in normal controls;miR-590 may play a role in the carcinogenesis of oral mucosal cells.关键词
微小RNA/miR-590/口腔扁平苔藓/口腔鳞癌Key words
microRNA/miR-590/oral lichen planus/oral squamous carcinoma分类
医药卫生引用本文复制引用
吴岩,田宏伟,杜美仪..口腔扁平苔藓及口腔鳞癌患者口腔黏膜组织中微小RNA-590表达研究[J].中国实用口腔科杂志,2018,11(1):48-51,4.
