中国现代医学杂志2018，Vol.28Issue(6)：50-53,4.DOI:10.3969/j.issn.1005-8982.2018.06.009
缺氧诱导因子1α与甘氨酸甲基转移酶在胃癌组织中的表达及其临床意义
Effect of HIF- 1α and glycine methyltransferase on prognosis of gastric cancer
达热拜·热达提 1赵为民 1曾祥岳 1杨新辉1
作者信息
- 1. 新疆医科大学附属肿瘤医院 胃肠外科,新疆 乌鲁木齐 830011
- 折叠
摘要
Abstract
Objective To investigate the expression levels of hypoxia inducible factor-1α (HIF-1α) and glycine methyltransferase (GNMT) in patients with gastric cancer and potential association with prognosis. Methods Totally 45 cases of gastric cancer patients admitted to our hospital from June 2015 to June 2016 were included in this study. Cancer tissues and adjacent normal tissues were collected for further purposes. Expression of HIF-1α and GNMT were determined by Immunostaining method. Potential association between expression of target proteins and clinical outcome was analyzed. Results The positive rate of HIF-1α in gastric carcinoma was increased significantly compared with normal tissue (84.44% vs 4.45%, P < 0.05). Among HIF-1α expressing cells, nucleus positive rate was dramatically higher compared with cytoplasm positive rate (64.44% vs 4.45%, P < 0.05). Concentration of GNMT in gastric cancer tissue was downregulated when compared with that in normal tissue [(678.23 ± 221.88) ng/ml vs (1,136.73 ± 332.81) ng/ml, P < 0.05]. Multivariate Cox regression analysis showed that the independent factors for 5 year survival of patients included HIF-1 α protein (+) (P = 0.002), GNMT protein (-) (P = 0.006), differentiation degree (P = 0.036), invasion depth (P = 0.001), and distant metastasis (P = 0.002). Conclusion Expression of HIF-1α increases while GNMT decreases in gastric cancer tissue, which may be the prognostic factors for outcome of gastric tumor.关键词
缺氧诱导因子1α/甘氨酸甲基转移酶/胃癌组织/癌旁正常组织Key words
hypoxia inducible factor 1α/glycine methyltransferase/gastric cancernormal tissue adjacent to cancer分类
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达热拜·热达提,赵为民,曾祥岳,杨新辉..缺氧诱导因子1α与甘氨酸甲基转移酶在胃癌组织中的表达及其临床意义[J].中国现代医学杂志,2018,28(6):50-53,4.
