中国现代医学杂志2018，Vol.28Issue(6)：76-80,5.DOI:10.3969/j.issn.1005-8982.2018.06.014
结直肠癌远处转移患者治疗前LMR值与化疗疗效和死亡风险的相关性研究
Prognostic value of LMR on patients with distant metastasis of colorectal cancer prior to therapeutic interventions
徐辉 1张汝一 1姬清华 1程海玉 1尹朝晖1
作者信息
- 1. 贵州医科大学附属医院 肛肠外科,贵州 贵阳 550004
- 折叠
摘要
Abstract
Objective To investigate the prognostic value of LMR on patients with distant metastasis of colorectal cancer prior to therapeutic interventions and potential association between them. Methods A total of 95 patients diagnosed with colorectal cancer accompanied by distant metastasis were included in this study. LMR value of all patients were recorded before any treatments. ROC prediction model was established for correlation analysis between LMR and progression-free survival and overall survival. The Cox regression equation was utilized to identify the predictive effect of LMR on overall outcome. Results Among 95 cases, chemotherapy resulted in 2 cases of complete remission (2.4%), 28 cases of partial remission (29.47%), 45 cases in stable status (47.37%), and 20 cases in progressive disease (21.05%). The AUC of the LMR versus chemotherapy efficacy in ROC model was 0.950 (95% CI: 0.906, 0.995). Threshold of LMR was 5.565 with sensitivity as 0.932 and specificity as 0.952. Progression-free survival and total survival were positively associated with increase of LMR. The linear equations of LMR over progression-free survival and total survival were (y = 0.3978x+13.191) and (y = 0.3693x+19.367), respectively. Based on data from follow-up, the survival rate in group of patients with high LMR increased dramatically when compared with patients with low LMR (40.63% vs 3.23%, P = 0.000). Cox regression analysis showed that low value of LMR could be an independent risk factor of colorectal cancer. Conclusion LMR value in colorectal cancer patients with distant metastasis prior to any treatments may be positively associated with chemotherapy efficacy and clinical outcomes.关键词
结直肠癌/远处转移/淋巴细胞/单核细胞比值/化疗疗效/死亡风险Key words
colorectal cancer/distant metastasis/LMR/chemotherapy efficacy/risk of death分类
医药卫生引用本文复制引用
徐辉,张汝一,姬清华,程海玉,尹朝晖..结直肠癌远处转移患者治疗前LMR值与化疗疗效和死亡风险的相关性研究[J].中国现代医学杂志,2018,28(6):76-80,5.
