中国现代医学杂志2018，Vol.28Issue(7)：55-60,6.DOI:10.3969/j.issn.1005-8982.2018.07.011
Survivin mRNA和CK19 mRNA在胃癌患者外周血中的表达及临床意义
Expressions of Survivin mRNA and CK19 mRNA in peripheral blood of patients with gastric cancer and clinical significance
陈国飞 1杨华 2蒋幸新 1王波 3徐艳1
作者信息
- 1. 江苏省苏州市中西医结合医院 检验科,江苏 苏州 215000
- 2. 江苏省苏州市中西医结合医院 内四科,江苏 苏州 215000
- 3. 江苏省苏州市吴中人民医院 内科,江苏 苏州 215128
- 折叠
摘要
Abstract
Objective To explore the expressions of Survivin mRNA and CK19 mRNA in the peripheral blood of the patients with gastric cancer and their clinical significance. Methods Expressions of Survivin mRNA and CK19 mRNA in peripheral blood were analyzed by RT-PCR in 89 patients with gastric cancer. Statistical analysis was conducted to analyze the diagnostic and prognostic value of Survivin mRNA and CK19 mRNA in the peripheral blood of the patients with gastric cancer. Results RT-PCR revealed that the Survivin mRNA and CK19 mRNA were both significantly higher in the peripheral blood of the patients with gastric cancer than in the normal controls. ROC curves revealed that both Survivin mRNA and CK19 mRNA were promising diagnostic biomarkers for gastric cancer. Chi-square test revealed that both Survivin mRNA and CK19 mRNA expressions were positively associated with TNM stage of the patients with gastric cancer. Kaplan-Meier curves revealed that the patients with gastric cancer which were both Survivin-positive and CK19-positive had the lowest 5-year survival rate after surgery, which was statistically significant. Conclusions Survivin mRNA and CK19 mRNA are upregulated in the peripheral blood of the patients with gastric cancer. They are promising biomarkers for early diagnosis and prognostic prediction of the patients with gastric cancer.关键词
Survivin/CK19/诊断/预后/胃癌Key words
Survivin/CK19/diagnosis/prognosis/gastric cancer分类
医药卫生引用本文复制引用
陈国飞,杨华,蒋幸新,王波,徐艳..Survivin mRNA和CK19 mRNA在胃癌患者外周血中的表达及临床意义[J].中国现代医学杂志,2018,28(7):55-60,6.
