中国现代医学杂志2018，Vol.28Issue(7)：74-78,5.DOI:10.3969/j.issn.1005-8982.2018.07.015
乌司他丁对老年患者直肠癌根治术后认知功能障碍的影响
Effect of Ulinastatin on postoperative cognitive dysfunction in elderly patients undergoing laparoscopic radical resection of rectal cancer*
摘要
Abstract
Objective To observe the influence of Ulinastatin on postoperative cognitive dysfunction (POCD) in the elderly patients undergoing laparoscopic radical resection of rectal cancer. Methods Sixty elderly patients scheduled for laparoscopic radical resection of rectal cancer were randomly allocated to control group and observation group with 30 in each. The patients in the observation group received sustained intravenous injection of 100,000 U/h Ulinastatin after injection of 200,000 U before anesthesia induction. Those in the control group received the same dosages of normal saline. The plasma concentrations of IL-6, TNF-α and S100β were determined 1 day before operation (T0), at the end of operation (T1), 1 day (T2) and 3 day (T3) after operation. Postoperative cognitive dysfunction was assessed by Mini-mental State Examination (MMSE) at T0, T2and T3. Results The levels of IL-6, TNF-α and S100β were the highest at T1in both groups (P < 0.05). In the control group, the levels of IL-6 and TNF-α at T2were higher than those at T0and T3(P < 0.05). The levels of IL-6, TNF-α and S100β were significantly lower in the observation group than in the control group at T1(P < 0.05). Compared with the control group, the levels of IL-6 and TNF-α were lower and MMSE scores were higher in the observation group at T2(P < 0.05). In addition, MMSE scores at T2were lower than those at T0and T3in the control group (P < 0.05). Finally, the incidence of POCD was lower in the observation group (P < 0.05). Conclusions Ulinastatin can decrease the plasma concentrations of IL-6, TNF-α and S100β and reduce the risk of POCD in the elderly patients undergoing laparoscopic radical resection of rectal cancer.关键词
乌司他丁/老年人/直肠癌根治术/术后认知功能障碍Key words
Ulinastatin/elderly/radical resection of rectal cancer/postoperative cognitive dysfunction分类
医药卫生引用本文复制引用
丁登峰,刁文波,黄强,马磊,董心童,张雪萍..乌司他丁对老年患者直肠癌根治术后认知功能障碍的影响[J].中国现代医学杂志,2018,28(7):74-78,5.基金项目
深圳市科技计划项目(No:JCYJ20140416122812032) （No:JCYJ20140416122812032）
深圳市卫生计生系统科研项目(No:201501005) （No:201501005）
