摘要
Abstract
Objective To investigate the effect of different dosages of Dezocine on bispectral index (BIS) and auditory-evoked potentials index (AEPI) under general anesthesia with target-controlled injection of Propofol. Methods Totally 100 patients who had operation under general anesthesia in our hospital from October 2014 to July 2015 were divided into 4 groups, with 25 patients in each group. All patients received target-controlled injection of Propofo1. They were then intravenously infused with 0.05, 0.10, 0.15 mg/kg Dezocine (group D1, D2, D3, respectively), or 1 μg/kg Fentanyl (group F). Heart rate (HR), mean arterial blood pressure (MAP), BIS and AEPI were measured before induction of general anesthesia (T), immediately before drug administration (T0), and every 3 min after administration up to 15 min. Results There were no significant differences among HR, MAP, BIS or AEPI values at different time points in the group F (P > 0.05). Compared with the values of the group F at each time point, HR, MAP, BIS and AEPI values of the group D1 increased significantly, HR and MAP values of the group D2 increased significantly (P < 0.05); but there were no significant differences between the group D3 and the group F at each time point (P > 0.05). Compared with the T0values, HR, MAP, BIS and AEPI values of the group D1 increased significantly at other time points (P < 0.05), and HR, BIS and AEPI values of the group D2 increased significantly, MAP values of the group D3 significantly increased at T2-T5(P < 0.05). Conclusions Different dosages of Dezocine have certain influence on hemodynamic parameters and depth of anesthesia in patients undergoing Propofol general anesthesia. General anesthesia can use 0.15 mg/kg Dezocine, which can achieve effective depth of anesthesia and maintain preoperative stable hemodynamics. It is worthy of clinical application.关键词
地佐辛/丙泊酚/脑电双频指数/听觉诱发电位指数Key words
Dezocine/Propofol/bispectral index/auditory-evoked potential index分类
医药卫生
