中国现代医学杂志2018，Vol.28Issue(7)：105-108,4.DOI:10.3969/j.issn.1005-8982.2018.07.021
PR-SET7在食管癌中表达及其临床意义
PR-SET7 is expressed in human esophageal carcinoma and its clinical significance
郑建 1陈建 1叶钢1
作者信息
- 1. 武警江苏省总队医院 胸外科,江苏 扬州 225003
- 折叠
摘要
Abstract
Objectgive To investigate the lysine methyltransferase (PR-SET7) expression in human esophageal cancer tissues and its correlation with clinical features. Methods The immunohistochemistry was used to detect the PR-SET7 expressions in esophageal cancer tissues and adjacent normal tissues of 32 cases at Jiangsu Armed Police General Hospital from June 2010 to February 2011. And the correlations of PR-SET7 expression with patients' gender, age, degree of carcinoma tissue differentiation, TNM stage and lymph node metastasis were explored. Results Immunohistochemical results showed that PR-SET7 expression was found in all 32 cases of esophageal cancer tissues, and the expression of PR-SET7 in the cancerous tissues was significantly stronger than that of the adjacent tissues. The high-expression rate was 81.25% in theesophageal cancer tissues, the adjacent tissues chiefly had weak expression of PR-SET7 with the high-expression rate of 15.62% (P < 0.05). PR-SET7 mainly expressed in the nuclei of tumor cells. PR-SET7 protein level in the patients with esophageal carcinoma was not correlated with age or sex (P > 0.05), but correlated with tumor cell differentiation, TNM stage and lymph node metastasis (P < 0.05). Conclusions Abnormal expression of PR-SET7 could be found in the process of oncogenesis and progression of esophageal cancer, its expression level is closely associated with tumor pregression, metastasis and prognosis.关键词
PR-SET7/食管癌/表达/预后Key words
PR-SET7/esophageal carcinoma/expression/prognosis分类
医药卫生引用本文复制引用
郑建,陈建,叶钢..PR-SET7在食管癌中表达及其临床意义[J].中国现代医学杂志,2018,28(7):105-108,4.
