中国现代医学杂志2018，Vol.28Issue(7)：112-115,4.DOI:10.3969/j.issn.1005-8982.2018.07.023
不同时间点利伐沙班预防髋关节置换术后深静脉血栓形成的疗效研究
Efficacy of using Rivaroxaban at different time for prevention of deep venous thrombosis after hip replacement*
摘要
Abstract
Objective To compare the effect and safety of using Rivaroxaban to prevent deep venous thrombosis (DVT) at different time in the perioperative stage. Methods There were 150 hip replacement patients in our hospital from January 2014 to October 2016. Based on the admission criteria, they were randomly divided into 4 groups. The patients in the group A used Rivaroxaban 72 h before operation. The patients in the group B used Rivaroxaban 48 h prior to the surgery. The patients in the group C used Rivaroxaban 24 h in advance to the operation. The patients in the group D used Rivaroxaban 6 h before operation. The incidence of DVT and hemorrhagic complications in the 4 groups of patients were observed. The perioperative bleeding volume was also recorded. Results In the groups A, there was 1 case of DVT, and the incidence was 2.5%. In the group B, 4 cases had DVT, the incidence was 11.1%. In the group C, 5 cases had DVT, the incidence was 13.2%. In the group D, 11 cases had DVT, the incidence was 30.6%. The DVT incidence of the group A was obviously lower than those in the groups B, C and D, and the differences were statistically significant (P < 0.05). The amount of hemorrhage in the perioperative stage among the 4 groups had no statistical meaning (P > 0.05). Conclusions Using Rivaroxaban 72 h before operation has better effect and higher safety in the prevention of DVT after hip replacement.关键词
髋关节置换术/围手术期/深静脉血栓/利伐沙班Key words
hip replacement/perioperative stage/deep venous thrombosis/Rivaroxaban分类
医药卫生引用本文复制引用
刘剑伟,蒋卫平..不同时间点利伐沙班预防髋关节置换术后深静脉血栓形成的疗效研究[J].中国现代医学杂志,2018,28(7):112-115,4.基金项目
广西壮族自治区卫计委科研课题(No:Z2014459) （No:Z2014459）
