中国畜牧兽医2017，Vol.44Issue(11)：3149-3155,7.DOI:10.16431/j.cnki.1671-7236.2017.11.007
可溶性环氧化物水解酶抑制剂的降血糖功效研究
Hypoglycemic Effect of Soluble Epoxide Hydrolase Inhibitors on Diabetic Mice
摘要
Abstract
In order to study the hypoglycemic effect of soluble epoxide hydrolase inhibitors (sEHI) on diabetic mice,the diabetic mice model were successfully induced by high-fat diet and streptozotocin (STZ).The diabetic mice (C57BL/6J) were randomly divided into three groups,including normal control group,diabetic control group and sEHI group,the mice in three groups were fed high-fat diet+1 mg/kg sEHI (t-AUCB),high-fat diet+same volume normal saline,normal diet+same volume normal saline,respectively,and intervention last for 4 weeks.During the experiment,the body weight,blood glucose were recorded,and performed oral glucose tolerance test was conducted.After the experiment,indicators of serum lipids,liver peroxidation and pathological analysis of pancreatic tissue were measured.The results showed that compared with diabetic control group,the fasting blood glucose of mice in sEHI group was significantly reduced (P＜0.05),and their glucose tolerance was improved.And the TC (P＜0.05),TG (P＜0.05) and LDL (P＞0.05) in sEHI group were decreased,while the LDL/TC was significantly increased (P＜0.05).The SOD and CAT activity in liver of diabetic mice treated with sEHI were significantly increased (P＜0.05) and MDA activity was significantly decreased (P＜0.05).Based on mouse pancreatic tissue sections,we speculated that sEHI had ability to repair activity on damaged islet tissue.In conclusion,the sEHI could reduce the blood glucose level and the free radical damage,inhibit lipid peroxidation,repair of damaged islet tissue in mice.关键词
Ⅱ型糖尿病/可溶性环氧化物水解酶抑制剂/降血糖/血脂指标Key words
type Ⅱ diabetes/soluble epoxide hydrolase inhibitors (sEHI)/antidiabetics/serum lipid parameter分类
医药卫生引用本文复制引用
高婉婷,明亮,何静,白娜,郭雁,伊日贵,吉日木图..可溶性环氧化物水解酶抑制剂的降血糖功效研究[J].中国畜牧兽医,2017,44(11):3149-3155,7.基金项目
国家自然科学基金项目(31360397) （31360397）
国际科技合作项目(2015DFR30680、ky201401002) （2015DFR30680、ky201401002）
内蒙古重大专项 （）
