中国药房2017，Vol.28Issue(32)：4478-4482,5.DOI:10.6039/j.issn.1001-0408.2017.32.04
应用中医传承辅助平台分析冠心病不稳定型心绞痛方剂的组方用药规律
Analysis of the Regularity of Drug Use in Coronary Heart Disease Unstable Angina Prescriptions by TCM Inheritance Auxiliary Platform
摘要
Abstract
OBJECTIVE:To provide reference for TCM in the treatment of coronary heart disease (CHD) unstable angina and new drug research and development.METHODS:TCM inheritance auxiliary platform software was adopted to build prescription database of TCM in the treatment of CHD unstable angina.The software function of clinical collection,platform management,information management,knowledge retrieval,statistics,data analysis were adopted to analyze prescription database in respects of four properties,five tastes,channel tropism distribution,frequency statistics,rules of prescriptions and potential new prescriptions,etc.RESULTS:Through analyzing 178 prescriptions of CHD unstable angina,152 ingredients were involved.Top 3 in the list of distribution frequency of four properties were warm (617),cold (474) and mild (288).Top 3 in the list of distribution frequency of five tastes were bitter (750),sweet (732) and pungent (497).Top 3 in the list of distribution frequency of channel tropism were liver (860),heart (573) and spleen (549).A total of 40 ingredients were used more than 10 times,and top 5 were Ligusticum chuanxiong,Salvia miltiorrhiza,Astragalus membranaceus,Angelica sinensis and Carthamus tinctorious.According to the frequency of the drug combination,top 5 in descending order were L.chuanxiong-S.miltiorrhiza,L.chuanxiong-A.sinensis,L.chuanxiong-A.membranaceus,C.tinctorious-L.chuanxiong and S.miltiorrhiza-A.membranaceus.A total of 8 new prescriptions were obtained after evolution.CONCLUSIONS:Main prescriptions for CHD unstable angina included in CNKI are mild drug property,sweetness and bitterness in taste.Main selected ingredients can promote blood circulation,remove blood stasis and relieve pain,relieve restlessness and tranquilize the mind.It embodies the CHD unstable angina treatment principles of "treat both the incidental and fundamental aspects,tonification and purgation in combination".关键词
冠心病不稳定型心绞痛/中医传承辅助平台/方剂/组方规律Key words
Coronary heart disease unstable angina/TCM inheritance auxiliary platform/Prescription/Regularity分类
医药卫生引用本文复制引用
侯王君,庄贺,薛一涛,刘伟,夏明峰,庄慧魁..应用中医传承辅助平台分析冠心病不稳定型心绞痛方剂的组方用药规律[J].中国药房,2017,28(32):4478-4482,5.基金项目
国家自然科学基金资助项目(No.81273703) （No.81273703）
