中国药房2017，Vol.28Issue(32)：4513-4516,4.DOI:10.6039/j.issn.1001-0408.2017.32.13
右美托咪定对Wilson病继发脾功能亢进患者全身麻醉下脾切除术后躁动的影响
Effects of Dexmedetomidine on Agitation of Wilson's Disease Patients with Secondary Hypersplenism after General Anesthesia of Splonectomy
摘要
Abstract
OBJECTIVE:To observe the effects of dexmedetomidine (Dex) on postoperative agitation of Wilson's disease patients with secondary hypersplenism after genernl anesthesia of splenectomy.METHODS:A total of 60 Wilson's disease patients with secondary hypersplenism underwent general anesthesia of splenectomy duning Jan.-Dec.2016 were divided into control group and observation group according to random number table,with 30 cases in each group.Observation group was given intravenous pump of Dex 0.4 μg/kg at constant speed 15 min before anesthesia induction,and then maintained at 0.4 tg/(kg·h)till splenectomy completed.Control group was given constant volume of normal saline.Other anesthesia plans were same in 2 groups.Mean arterial pressure (MAP),heart rate (HR) and pulse oxygen saturation (SpO2) of 2 groups were observed before pumping (T0),before intubation (T1),1 min after intubation (T2),before extubation (T3),3 min after extubation (T4).Riker sedation-agitation score (SAS) were recorded in 2 groups at T3 and T4.The duration of stay in postanesthesia intensive care unit (PACU) and the occurrence of bradycardia were compared between 2 groups.RESULTS:At T0,there was no statistical significance in MAP,HR or SpO2 levels between 2 groups (P＞0.05).At T1,T2,T3 and T4,MAP and HR levels of 2 groups were decreased significantly,and the observation group was significantly lower than the control group,with statistical significance (P＜0.05).SpO2 were 100％ at each time point,there was no statistical significance between 2 groups (P＞0.05).Riker SAS scores of observation group was significantly lower than that of control group,with statistical significance (P＜0.05).The incidence of bradycardia in observation group was 26.67％,which was significantly higher than 3.33％ of control group,with statistical significance (P＜0.05).But this symptom was corrected after intravenous injection of atropine.The duration of stay in PACU in observation group was significantly shorter than control group,with statistical significance (P＜0.05).CONCLUSIONS:Dex can keep postoperative hemodynamics stable in Wilson's disease patients with secondary hypersplenism,reduce agitation and shorten the time of the patients transferring from PACU.关键词
右美托咪定/术后躁动/Wilson病/脾切除/全身麻醉Key words
Dexmedetomidine/Postoperative agitation/Wilson's disease/Splenectomy/General anesthesia分类
医药卫生引用本文复制引用
张永志,张野,张丁,季淼..右美托咪定对Wilson病继发脾功能亢进患者全身麻醉下脾切除术后躁动的影响[J].中国药房,2017,28(32):4513-4516,4.基金项目
国家自然科学基金资助项目(No.81471145) （No.81471145）
