中国药理学通报2018，Vol.34Issue(2)：166-170,5.DOI:10.3969/j.issn.1001-1978.2018.02.005
铁死亡的机制及其在神经疾病中的作用
Mechanism of ferroptosis and its role in neurological diseases
摘要
Abstract
Ferroptosis is distinct from apoptosis,autophagy,necrosis,cornification and other cell deaths from morphological,biochemical as well as genetic aspects.Ferroptosis plays a critical role in neurological diseases and cancers.Neurological diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,stroke,periventricular leukomalacia and so on,are characterized by multiple etiologies and mechanisms,and are potentially correlated with ferroptosis.Based on the recent researches on ferroptosis and neurological diseases,this review investigates ferroptosis and its role in neurological diseases.关键词
铁死亡/神经退行性疾病/阿尔茨海默病/帕金森综合征/亨廷顿舞蹈病/中风/脑室周围白质软化症Key words
ferroptosis/neurodegenerative disease/Alzheimer's disease/Parkinson's disease/Huntington's disease/stroke/periventricular leukomalacia分类
医药卫生引用本文复制引用
姜懿纳,阳松威,张欣,罗林明,张钊,陈乃宏..铁死亡的机制及其在神经疾病中的作用[J].中国药理学通报,2018,34(2):166-170,5.基金项目
国家自然科学基金资助项目(No 81373997) （No 81373997）
新药作用机制研究与药效评价北京市重点实验室资助项目(No BZ0150) （No BZ0150）
湖南省教育厅创新平台开放基金(No 15K091) （No 15K091）
湖南省科技厅课题(No 2015SK2029) （No 2015SK2029）
