中国药理学与毒理学杂志2017，Vol.31Issue(11)：1050-1056,7.DOI:10.3867/j.issn.1000-3002.2017.11.003
小胶质细胞的发育及在中枢神经系统的功能研究进展
Progress in microglia cell development and its function in central nervous system
摘要
Abstract
Microglia are a type of immune cells and widely distributed in the central nervous system(CNS), accounting for about 5% to 20% of the total number of glial cells. Microglia were first identified by Hortega using the silver carbonate method.It is believed that microglia originate from the mesoderm and invade the brain during the formation of blood vessels in the late embryonic development.Recent research shows that microglia are derived from yolk sac-derived macrophages. As a resident immune cell of the CNS,microglia belong to the monocyte-macrophage cell line and are an important immuno-logical defense against the invasion of pathogens. The resting microglia play a role in monitoring the nervous system to maintain the homeostasis.The activated microglia play a role in phagocytosis of cell debris and have neuroprotective and neurotoxic dual roles under different pathological conditions by secreting different cytokines.关键词
小胶质细胞/神经发育/中枢神经系统Key words
microglia/neural development/central nervous system分类
医药卫生引用本文复制引用
李忠秋,焦建伟..小胶质细胞的发育及在中枢神经系统的功能研究进展[J].中国药理学与毒理学杂志,2017,31(11):1050-1056,7.基金项目
国家自然科学基金(31730033) The project supported by National Natural Science Foundation of China(31730033) （31730033）
