中国药理学与毒理学杂志2017，Vol.31Issue(11)：1099-1105,7.DOI:10.3867/j.issn.1000-3002.2017.11.010
HCN通道在中枢神经系统的功能和调节机制研究进展
Role and functions of HCN channels in nervous system with complicated modulations
摘要
Abstract
Hyperpolarization-activated and cyclic nucleotide-gated(HCN)channels which are distributed in a variety of tissues including excitable cells such as heart cells and different neurons have important functions in the control of heart rate and neuronal excitability. Unlike the typical potassium channels and sodium channels,HCN channels can evoke inward currents while the membrane potential is hyper-polarized. Some studies have discovered that HCN channels were important for the nervous system, due to their special electrophysiological features and regulatory effects on the cellular membrane excit-ability.HCN channels are modulated by such factors such as extracellular molecules and intracellular sig-naling cascades, which make their functions quite special in the brain. Given their role, HCN channels seem to be promising targets for specific brain disease as well as chronic pain.In this review,we focus on the roles and functions of HCN channels with their complex modulator factors and neural activity.关键词
超极化激活环核苷酸门控的离子通道/慢性疼痛/抑郁/成瘾Key words
hyperpolarization-activated and cyclic nucleotide-gated channels/chronic pain/depression/addiction分类
医药卫生引用本文复制引用
翁谢川..HCN通道在中枢神经系统的功能和调节机制研究进展[J].中国药理学与毒理学杂志,2017,31(11):1099-1105,7.基金项目
北京市自然科学基金(7142123) （7142123）
蛋白质组学国家重点实验室优青课题(SKLP-YB201403) The project supported by Beijing Natural Science Foundation Project(7142123) （SKLP-YB201403）
and Project of National Key Laboratory of Proteomics(SKLP-YB201403) （SKLP-YB201403）
