肿瘤药学2018，Vol.8Issue(1)：44-48,5.DOI:10.3969/j.issn.2095-1264.2018.01.10
给药时间对口腔鳞癌患者DCF方案所致毒性的影响
Effect of Administration Time on Toxicity Induced by DCF in Patients with Oral Squamous Cell Carcinoma
摘要
Abstract
Objective To investigate the effects of different administration times on the toxicity of DCF regimen in order to better guide the clinical application. Methods 32 patients with oral squamous cell carcinoma were selected from March 2016 to August 2017 in our hospital. The patients were randomly divided into two groups. The experimental group was infused with fluorouracil around 10:00 and only docetaxel and cisplatin were infused around 18:30 on the first day. The control group received docetaxel and cisplatin after breakfast on the first day. Fluorouracil was infused using a micro-pump per day. The patient's blood parameters and adverse reactions were compared on the seventh day, the classification was determined according to the WHO chemotherapeutic toxicity classification criteria. Results There was no difference in the data between the two groups at baseline. On the 7th day after the starting of chemotherapy, compared with baseline data of patients, all patients showed several adverse reactions such as neutropenia, anemia and nausea, while a few adverse reactions such as thrombocytopenia, creatinine increase and hypokalemia occurred. The neutropenia, nausea, vomiting, several adverse reactions of patients in the two groups were statistically significant (P<0.05), the patients in experimental group improved significantly. The patients with febrile neutropenia, anemia, oral mucositis in experimental group also improved, however, no statistical difference was found (P>0.05). Conclusion Adjusted daytime use and evening administration of DCF chemotherapy can be more effective in reducing chemotherapeutic-induced neu-tropenia, nausea, vomiting and other toxic reactions, more researches to achieve better clinical use and reduce toxicity is needed.关键词
多西他赛/顺铂/氟尿嘧啶/口腔鳞癌/时间药理学Key words
Docetaxel/Cisplatin/Fluorouracil/Oral squamous cell carcinoma/Chronopharmacology分类
医药卫生引用本文复制引用
李永红,於海军,柯元,李伟,杨峥嵘..给药时间对口腔鳞癌患者DCF方案所致毒性的影响[J].肿瘤药学,2018,8(1):44-48,5.基金项目
国家自然科学基金青年项目(81201755). （81201755）
