肿瘤药学2018，Vol.8Issue(1)：69-72,4.DOI:10.3969/j.issn.2095-1264.2018.01.16
IL-6、CCL-18表达情况对乳腺癌病理诊断的相关性分析及其临床意义
The Diagnostic Value and Its Mechanism of IL-6 and CCL-18 for Breast Cancer
张晔 1石海英 2赵德芳 1王震霞 1张雅峰1
作者信息
- 1. 内蒙古医科大学附属医院普外科,内蒙古 呼和浩特,010050
- 2. 内蒙古医科大学附属医院保健中心,内蒙古 呼和浩特,010050
- 折叠
摘要
Abstract
Objective To investigate the diagnostic value and its mechanism of IL-6 and CCL-18 for breast cancer. Methods 32 pa-tients with breast cancer are selected as research subjects of breast cancer group, 28 patients with benign breast tumor are selected as re-search subjects of benign breast lesions group and 30 healthy subjects are selected as healthy control group were selected as the research subjects in our hospital from March 2013 to June 2015, the levels of IL-6 and CCL-18 in serum was measured by Enzyme linked immuno-sorbent assay (ELISA), the levels of serum IL-6 and CCL-18 between the three groups and different clinical stages in patients with breast cancer were compared, the relationship between IL-6、CCL-18 and clinical pathological parameters was also discussed. Results The levels of serum IL-6 and CCL-18 in breast cancer group and benign breast lesions group were significantly higher than healthy control group, and the serum IL-6, CCL-18 levels in the breast cancer group were significantly higher than benign breast lesions group, the difference was sta-tistically significant (P<0.05); The levels of serum IL-6 and CCL-18 were increased gradually with the increase of clinical stage in patients with breast cancer, the difference was statistically significant (P<0.05); The serum IL-6 level in the late stage of TNM (Ⅲ~Ⅳ), lymph node metastasis, Ki67 ≥20%, ER positive expression were significantly increased in patients with breast cancer, the difference was statistically significant (P<0.05); The serum CCL-18 level in the late stage of TNM (Ⅲ~Ⅳ)、Ki67 ≥20% were significantly increased in patients with breast cancer, the difference was statistically significant (P<0.05). Conclusion The level of IL-6 and CCL-18 were highly expressed in the serum of patients with breast cancer, which suggested that the patient's condition deteriorated and the prognosis was poor. The occurrence and development of breast cancer may be related to IL-6 and CCL-18.关键词
乳腺癌/白细胞介素-6/趋化因子配体18/作用机制Key words
Breast cancer/Interleukin-6/Chemokine ligand 18/Mechanism分类
医药卫生引用本文复制引用
张晔,石海英,赵德芳,王震霞,张雅峰..IL-6、CCL-18表达情况对乳腺癌病理诊断的相关性分析及其临床意义[J].肿瘤药学,2018,8(1):69-72,4.
