肿瘤药学2018，Vol.8Issue(1)：84-88,5.DOI:10.3969/j.issn.2095-1264.2018.01.19
晚期肺癌患者放化疗疗效及医院感染的危险因素分析
Efficacy of Radiotherapy and Chemotherapy by Different Ways for Patients with Advanced Lung Cancer and Risk Factors of Nosocomial Infections
摘要
Abstract
Objective To compare efficacy of two radiotherapy and chemotherapy methods in patients with advanced lung cancer, and to explore the risk factors of nosocomial infections. Methods 100 advanced lung cancer patients who underwent radiotherapy and chemo-therapy were collected as research subjects in our hospital from January 2014 to April 2017. All patients were randomly divided into experi-ment group and control group, 50 cases in each group. The patients in experiment group underwent concurrent chemoradiotherapy, and the patients in control group underwent sequential chemoradiotherapy. The short-term effects of patients between the two groups were com-pared. The nosocomial infections of patients in the two groups were detected. Single factor analysis and logistic analysis were used to analyze 9 factors including age and sex relations with nosocomial infection of advanced lung cancer patients in order to identify risk factors. Results The efficacy rate of patients in experiment group was 64.00%, which was significant higher than that in control group 44.00% (P<0.05). The efficacy rate of different pathological types and TNM periodizations in experiment group were significantly higher than those in control group (P<0.05). The nosocomial infection rate of advanced lung cancer patients underwent radiotherapy and chemotherapy was 24.00% (24/100), in which the main position was respiratory tract [50.00% (12/24)]. The single factor analysis showed that length of stay, invasive procedure, attended infection, leukocyte, serum creatinine, serum albumin, and antimicrobial use were related factors of nosocomial infection (P<0.05).Logistic regression analysis showed anti-microbial use (OR=2.769), length of stay >2 months (OR=2.704), and invasive procedure (OR=2.630) were the risk factors of nosocomial infection patients. Conclusion Compare to sequential chemoradiotherapy, concurrent chemoradiotherap has better short-term effect. Shortening length of stay, reduced invasive procedures, and reasonable application of antimicrobial agents can reduce infection rate of nosocomial infections.关键词
晚期肺癌/同步放化疗/序贯放化疗/医院感染/危险因素Key words
Advanced lung cancer/Concurrent chemoradiotherapy/Sequential chemoradiotherapy/Nosocomial infections/Risk factors分类
医药卫生引用本文复制引用
刘滔,王少龙,文峰,何小平,巫道琳,李亚军,周辉..晚期肺癌患者放化疗疗效及医院感染的危险因素分析[J].肿瘤药学,2018,8(1):84-88,5.基金项目
四川省卫生厅科研项目(110119) （110119）
湖南省卫计委项目(C2015-52) （C2015-52）
湖南省科技厅项目(2016JJ3083) （2016JJ3083）
湖南省重点研发项目(2017SK2133). （2017SK2133）
