中山大学学报（医学科学版）2018，Vol.39Issue(1)：152-156,5.
二氧化碳激光打孔预处理联合5-氨基酮戊酸光动力治疗难治性巨大跖疣
Treatment of Recalcitrant Plantar Warts with 5-aminolevulinic Acid Photodynamic Therapy(ALA-PDT)after Preconditioning with Superpulse Carbon Dioxide Laser
摘要
Abstract
[Objective]To investigate the efficacy and safety of ALA-PDT following CO2laser preconditioning for recal-citrant plantar warts.[Methods]Patients with recalcitrant plantar warts were enrolled in this study,and received ALA-PDT treatment following CO2laser preconditioning. Cure rate and side effects were observed.[Results]Twenty patients were en-rolled and 85%(17/20)showed complete clearance of plantar warts after one to three times of ALA-PDT. PDT treatment time was once in two patients(10%),twice in five patients(25%)while three times in 10 patients(50%).No infection or scar tissue was observed.Five(25%)patients were infected with one type of HPV,while 15(75%)patients with two or mul-tiple types of HPV. No difference was observed in complete clearance rate between patients with single or multiple HPV gen-otypes infection.[Conclusions]Superpulse carbon dioxide laser pretreatment enhanced the efficacy of ALA-PDT treatment on recalcitrant plantar warts.Further study is needed to determine the association of HPV genotype with outcome of recalci-trant plantar warts.关键词
跖疣/光动力治疗/二氧化碳激光/人乳头瘤病毒/基因型Key words
plantar wart/photodynamic therapy/carbon dioxide laser/Human papilloma virus/genotype分类
医药卫生引用本文复制引用
戴海蓉,周晖,李巧飞,凌宏忠,谢继璜,李玉华,曹光玲..二氧化碳激光打孔预处理联合5-氨基酮戊酸光动力治疗难治性巨大跖疣[J].中山大学学报（医学科学版）,2018,39(1):152-156,5.基金项目
广东省科技计划项目(2012B061700080) （2012B061700080）
