中医药信息2017，Vol.34Issue(6)：69-73,5.
清心消癥汤联合GnRH-α对中重度子宫内膜异位症保守性手术治疗后的观察分析
Therapy of GnRH-α Combined with Qingxin Xiaozheng Decoction in the Treatment of Moderate and Severe EMT after Conservative Surgery
摘要
Abstract
Objective:To compare the different clinical efficacy between the therapy of gonadotropin-releasing hormone agonist (GnRH-α) combined with Qingxin Xiaozheng decoction and the therapy of GnRH-α combined with Tibolone,after conservative surgery for moderate and severe endometriosis(EMT).Methods:40 patients were randomly assigned into the TCM group (n =20) and the hormone group (n =20),both groups were injected with GnRH-α (Zoladex,3.6mg,once per 28 days,six times) on the second day after surgery.When the symptoms of peri-menopausal period occurred,the TCM group was treated with Qingxin Xiaozheng decoction(three months at least);whereas the hormone group was given Tibolone(1.25 mg/d),the dosage was adjusted according to estradiol(E2) level.The treatment lasted for more than six months.Kupperman score(KIM),serum levels of E2 and cancer antigen125 (CA125),as well as the degree of menalgia and menstrual recovery time were observed in the two groups.Results:In terms of KIM score,it was higher in the TCM group after the 4th injection compared to the hormone group,with statistical significance(P ＜0.05);after the 6th injection,there was no statistical difference between the two groups (P ＞ 0.05).In terms of E2 level,there was statistical difference after the 6th injection between the two groups (P ＜ 0.05).In terms of CA125 level,there was no statistical difference between the two groups(P ＞ 0.05).In terms of menalgia degree and menstrual recovery time,there was no significant difference between the two groups after the treatment(P ＞ 0.05).Conclusions:The therapy of GnRH-α combined with Qingxin Xiaozheng decoction can increase serum level of E2,and it can achieve similar effect as hormone,but can avoid the disadvantages of hormone,when treating EMT after laparoscopy surgery.关键词
子宫内膜异位症/腹腔镜手术/GnRH-α/清心消癥汤Key words
Endometriosis/Laparoscopy surgery/GnRH-α/Qingxin Xiaozheng decoction分类
医药卫生引用本文复制引用
陈香,时燕萍..清心消癥汤联合GnRH-α对中重度子宫内膜异位症保守性手术治疗后的观察分析[J].中医药信息,2017,34(6):69-73,5.基金项目
江苏省中医药管理局支持项目(No.LZ13059) （No.LZ13059）
