组织工程与重建外科杂志2018，Vol.14Issue(1)：28-30,52,4.DOI:10.3969/j.issn.1673-0364.2018.01.008
骨髓间充质干细胞移植对周围神经损伤后施旺细胞的影响
Effects of BMSCs Transplantation on Schwann Cells after Peripheral Nerve Injury
邱超 1郑亚妮 1许硕贵1
作者信息
- 1. 200433上海市 第二军医大学附属长海医院急诊科
- 折叠
摘要
Abstract
Objective To explore the effects of bone marrow mesenchymal stem cells (BMSCs) transplantation on Schwann cells after peripheral nerve injury. Methods BMSCs were isolated from SD rats and cultured. Injury model of the sciatic nerve cross-sectional was established, and BMSCs were injected into the distal of injured sciatic nerve. HE staining and immunofluorescence staining were used to detect the morphology and quantity of Schwann cells. Results According to HE staining and immunofluorescence staining, after BMSCs was implanted, the number of Schwann cells in sciatic nerve increased, the cell structure was more clear and complete, and the arrangement was more orderly. Conclusion BMSCs transplantation can protect Schwann cells after sciatic nerve injury.BMSCs may be a candidate in cell transplantation therapy for peripheral nerve injury.关键词
骨髓间充质干细胞/坐骨神经/施旺细胞/移植Key words
Bone marrow mesenchymal stem cells/Sciatic nerve/Schwann cells/Transplantation分类
医药卫生引用本文复制引用
邱超,郑亚妮,许硕贵..骨髓间充质干细胞移植对周围神经损伤后施旺细胞的影响[J].组织工程与重建外科杂志,2018,14(1):28-30,52,4.
