重庆医学2018，Vol.47Issue(5)：618-621,625,5.DOI:10.3969/j.issn.1671-8348.2018.05.013
含铂类联合方案治疗复发或难治性NHL的临床分析
Clinical analysis on platinum-based combined chemotherapeutical regimens for treating relapsed or refractory non-Hodgkin lymphoma
摘要
Abstract
Objective To evaluate the efficacy and adverse reactions of platinum-based combined chemotherapeutical regimens in treating relapsed or refractory non-Hodgkin lymphoma(NHL).Methods The clinical data of 68 patients with relapsed or refractory NHL treated with platinum-based combined chemotherapeutical regimens in the Affiliated Tumor Hospital of Guangxi Medical University from January 2008 to December 2014 were retrospectively analyzed.The curative effect of related regimens,adverse reactions and related influence factors were analyzed.Results Sixty-eight cases received 283 cycles of chemotherapy.In all cases,11 cases(16.18 ％) achieved the complete response(CR),31 cases(45.59 ％) achieved the partial response(PR),the overall response rate(ORR) was 61.76％;the median progression-free survival(PFS) was 6.51 months(95％CI:4.97-8.04 months).ORR and PFS in the cases of stage Ⅱ-Ⅲ,IPI score 0-2 and receiving only one chemotherapeutical regimen were superior to those in the cases of corresponding subgroup(P＜0.05);ORR and PFS had no statistical difference between the B cells lymphoma and Tcells lymphoma(P＞0.05).The medion PFS in the combined R group was 11.16 months,which was longer than 5.84 months in the non-combined R group(P =0.004).The major adverse events (stage Ⅱ-Ⅲ) included leukopenia (41.18 ％),thrombocytopenia (27.94％),hemoglobin decrease(11.76％),vomiting(8.82％) and diarrhea(1.47％).Conclusion The platinum-based combined chemotherapeutical regimens are effective with good safety in the treatment of relapsed or refractory NHL.关键词
淋巴瘤,非霍奇金/复发/难治性/铂类/药物疗法,联合Key words
lymphoma, non-Hodgkin/relapse/refractory/platinum/drug therapy, combination分类
医药卫生引用本文复制引用
王洪学,谢伟敏,陈梅林,覃芳卉,周文献,贾昱娴,陈军,岑洪,谢裕安,陆永奎..含铂类联合方案治疗复发或难治性NHL的临床分析[J].重庆医学,2018,47(5):618-621,625,5.基金项目
国家自然科学基金资助项目(81160298) （81160298）
广西自然科学基金资助项目(桂科基0342010-7) （桂科基0342010-7）
广西医药卫生计划课题(重2012096). （重2012096）
