重庆医学2018，Vol.47Issue(5)：626-628,632,4.DOI:10.3969/j.issn.1671-8348.2018.05.015
垂体腺瘤患者胰岛素抵抗和皮质醇水平的相关性研究
Correlation study between insulin resistance and cortisol level in patients with pituitary adenoma
摘要
Abstract
Objective To explore the insulin resistance(IR),serum cortisol.level and circadian secretion rhythm in the patients with pituitary adenoma(PA).Methods Sixty-seven patients with PA in this hospital from October 2016 to April 2017 were selected as the observation group,including 23 cases of pituitary Cushing syndrome,15 cases of growth hormone adenoma,16 cases of prolactinoma and 13 cases of non-functioning adenoma.Contemporaneous 49 individuals undergoing healthy physical examination were selected as the control group.The biochemical indexes of fasting plasma glucose(FPG),fasting insulin(FINS) and serum cortisol were measured and the homeostasis model assessment for insulin resistance(HOMA-IR) was determined.The correlation between insulin resistance and serum cortisol was analyzed.Results The incidence rate of cortisol circadian rhythm disorder in the observation group was 58.21％,the level of fasting serum cortisol in abnormal secretion rhythm of PA group was higher than that in normal secretion rhythm of PA group and control group(P＜0.05);the levels of FINS and HOMA-IR in the pituitary Cushing syndrome and growth hormone adenoma group were higher than those in the control group,the correlation analysis showed that HOMA-IR in PA patients was positively correlated with fasting serum cortisol level and FINS level(P＜0.05).Conclusion The IR occurrence exists in pituitary Cushing syndrome and growth hormone adenoma,which may be closely correlated with serum cortisol increase.关键词
垂体腺瘤/胰岛素抵抗/皮质醇/昼夜节律/相关性分析Key words
pituitary adenoma/insulin resistance/cortisol/circadian rhythm/correlation analysis分类
医药卫生引用本文复制引用
罗艺,吕民,刘艳源,胡汉宁,陈薇..垂体腺瘤患者胰岛素抵抗和皮质醇水平的相关性研究[J].重庆医学,2018,47(5):626-628,632,4.基金项目
国家自然科学基金资助项目(81501033) （81501033）
湖北省卫生计生科研基金资助项目(WJ2017M038) （WJ2017M038）
武汉市科技局基础应用研究计划项目 (2015060101010056). （2015060101010056）
