重庆医学2018，Vol.47Issue(5)：635-637,3.DOI:10.3969/j.issn.1671-8348.2018.05.018
PD-1、PD-L1在喉癌中的表达及临床意义
Expression of PD-1 and PD-L1 in laryngeal carcinoma and its clinical significance
摘要
Abstract
Objective To investigate the relationship between programmed death 1 (PD-1) and programmed death ligand 1(PD-L1) with clinicopathological characteristics in the patients with laryngeal carcinoma.Methods The expression levels of PD-1 and PD-L1 in 45 samples of laryngeal carcinoma tissue(laryngeal carcinoma group) and 37 samples of vocal cord polyp tissues(polyp group) were detected by using the immunohistochemical method.Then the relationship between PD-1 and PD-L1 with clinicopathological characteristics in the patients with laryngeal carcinoma was analyzed.Results The positive expression rates of PD-1 and PD-L1 in the laryngeal carcinoma group were 57.78％ and 66.67 ％ respectively.PD-1,PD-L1 mainly located in cytoplasm or cell membrane of laryngeal carcinoma cells or interstitial lymphocyte.The positive expression rates of PD-1 and PD-L1 in the polyp group were 8.11％ and 13.51％ respectively.The positive expression rates of PD-1 and PD-L1 in the laryngeal carcinoma group were significantly higher than those in the polyp group(P＜0.01).The expression of PD-1 and PD-L1 in laryngeal carcinoma tissue had a correlation.The positive expression rates of PD-1 and PD-L1 in the laryngeal carcinoma tissue of stage Ⅲ and Ⅳ were significantly higher than those of stage Ⅰ and Ⅱ (P＜0.05).The positive expression rates of PD-1 and PD-L1 in highly differentiated laryngeal carcinoma tissue were significantly higher than those in moderately and lowly differentiated carcinoma tissue(P＜0.05).Conclusion PD-1 and PD-L1 play an important role in the occurrence and development of laryngeal carcinoma.The expression of PD-1 and PD-L1 is closely correlated to the clinical stage and differentiation degree of laryngeal carcinoma.关键词
喉肿瘤/程序性死亡因子1/程序性死亡因子配体1/免疫组织化学Key words
laryngeal neoplasms/programmed death 1/programmed death ligand 1/immunohistochemistry分类
医药卫生引用本文复制引用
张再兴,周尚清..PD-1、PD-L1在喉癌中的表达及临床意义[J].重庆医学,2018,47(5):635-637,3.基金项目
河北省医学科学研究重点课题计划(ZD-20140214). （ZD-20140214）
