重庆医学2018，Vol.47Issue(6)：733-735,739,4.DOI:10.3969/j.issn.1671-8348.2018.06.004
柚皮苷对心肌缺血-再灌注损伤大鼠血流动力学的影响
Effects of naringin on hemodynamics in myocardial ischemia-reperfusion injury rats
摘要
Abstract
Objective To observe the effects of naringin (Nar) on hemodynamics in myocardial ischemia-reperfusion(MI/R) injury rats for investigating its protective role on MI/R rats.Methods The ischemia-reperfusion(I/R) model was prepared by ligating the left anterior descending coronary artery,meanwhile different doses of Nar(10,20,40 mg/kg) were given.Then the electrocardiogram (ECG) was recorded after 7 d.The left ventricular end diastolic pressure (LVEDP),left ventricular systolic pressure (LVSP) and maximum ascending rate of left ventricular pressure/maximal descending rate of left ventricular pressure (±dp/dtmax) were measured.The activities of srum creatine kinase (CK) and lactate dehydrogenase (LDH) were measured by using the chemical colorimetry method.Results Compared with the MI/R group,Nar 20,40 mg/kg could decrease LVEDP,increased ±dp/ dtmax and LVSP,and decreased the activities of serum CK and LDH (P＜0.05),showing a dose-dependent manner.Conclusion Nar has the protective effect against MI/R injury rat and alleviates the myocardial damage extent,which may be related with improving the hemodynamics.关键词
柚皮苷/心肌缺血-再灌注损伤/血流动力学Key words
naringin/myocardial ischemia-reperfusion injury/hemodynamic分类
医药卫生引用本文复制引用
刘丹,金良友,冯晓灵,李小山,张永慧..柚皮苷对心肌缺血-再灌注损伤大鼠血流动力学的影响[J].重庆医学,2018,47(6):733-735,739,4.基金项目
重庆市教委科学技术研究项目(KJ1402501) （KJ1402501）
重庆市卫生和计划生育委员会中医药科技项目(ZY201703077) （ZY201703077）
重庆市万州区科学技术项目(201403051). （201403051）
