重庆医学2018，Vol.47Issue(6)：744-747,4.DOI:10.3969/j.issn.1671-8348.2018.06.007
ALR在急性肾损伤早期诊断中的价值评估及临床意义
Value assessment and clinical significance of ALR in early diagnosis of acute kidney injury
摘要
Abstract
Objective To explore whether augmenter of liver regeneration (ALR) can serve as early diagnostic biomarker in the patients with acute kidney injury(AKI).Methods The inpatients with possibility to AKI in the central ICU of Second Affiliated Hospital of Chongqing Medical University from October 2014 to October 2015 were recruited and assigned to the AKI group and non-AKI group according to the KDIGO guidance.Blood and urine ALR and blood creatinine were detected at 0,6,12,24,48,72 h after entering the group.Results Among all cases,40 cases(62.5％) developed to AKI.Blood ALR and urine ALR at 6h after entering the group in the AKI group began to significantly increase compared with the non-AKI group(P＜0.05),the blood and urine ALR levels reached to the peak value at 12,24 h after entering the group;the blood creatinine level at 12 h after entering the group in the AKI group began to significantly increase compared with the non-AKI group(P＜0.05),blood creatinine level was still slowly and progressively elevated at 72 h after entering the group.Conclusion Serum and urine ALR levels are significantly increased in the early stage of AKI,which indicates that ALR may be a new type biomarker for diagnosing AKI.关键词
肝再生增强因子/急性肾损伤/生物标志物Key words
augmenter of liver regeneration/acute kidney injury/biomarker分类
医药卫生引用本文复制引用
田媛,张玲,苏圆圆,张安,钟玲,谢树钦,廖晓辉..ALR在急性肾损伤早期诊断中的价值评估及临床意义[J].重庆医学,2018,47(6):744-747,4.基金项目
国家自然科学基金资助项目(81000299 （）
30971364) （）
国家临床重点专科建设项目经费资助(卫生办医政[2012]649) （卫生办医政[2012]649）
重庆市科委基础与前沿一般项目(cstc2015jcyjA10069) （cstc2015jcyjA10069）
重庆市卫生计生委医学科研计划面上项目(20142031) （20142031）
重庆医科大学科研培育基金项目(201404). （201404）
