摘要
Abstract
Objective To observe the effect of paliperidone extended-release tablets on clinical symptoms and cognitive function in patients with acute schizophrenia.Methods 64 patients with acute schizophrenia treated at our hospital from January,2015 to January,2017 were selected and were divided into an observation group and a control group by random number table,32 cases for each group.The control group were treated with haloperidol and the observation group with paliperidone extended-release tablets.After fourmonth treatment,the improvement of mental symptoms and cognitive function were compared between the two groups.Results As treatment time prolonged,the mental symptoms of the two groups significantly improved,and the observation group was better than the control group (P ＜ 0.05).As treatment time prolonged,the scores of cognitive function in the two groups gradually increased,and the scores of the observation group at each time point were higher than those of the control group (P ＜ 0.05).No significant adverse reactions occurred in the two groups during treatment,with well tolerance.Conclusion Paliperidone extended-release tablets in the treatment of acute schizophrenia is effective and can significantly relieve the patients' mental symptoms and improve cognitive function and causes no significant adverse reactions during treatment and is safe and reliable.关键词
急性期精神分裂症/帕利哌酮缓释片/临床症状/认知功能Key words
Acute schizophrenia/Paliperidone extended-release tablets/Clinical symptoms/Cognitive function
