老年医学与保健2018，Vol.24Issue(1)：14-17,4.
支气管肺泡灌洗液半乳甘露聚糖诊断老年肺曲霉病的研究
BALF-GM in the Diagnosis of Elderly Pulmonary Aspergillosis
摘要
Abstract
Objective To compare the values of bronchoalveolar lavage fluid Aspergillus galactomannan antigen (BALF-GM),serum GM,aspergillus fumigatus serum IgG,IgM antibody in the early diagnosis of invasive pulmonary aspergillosis (IPA) in the elderly non-neutropenic patients.Methods The levels of BALF-GM,serum GM,serum IgG and IgM of the patients clinically suspected to be with IPA infection were detected by enzyme-linked reaction adsorption test (ELISA).Result The sensitivity,specificity and negative predictive value of BALF-GM were higher while the positive predictive value was lower than those of serum GM;the level of BALF-GM in patients with aspergillus infection was significantly higher than that of serum GM (P ＜ 0.05) and higher than the level of BALF-GM in patients with bacterial infection (P ＜ 0.05);the optimal BALF GM cutoff value was 0.61;the sensitivity,specificity,positive predictive value and negative predictive value of serum Aspergillus fumigatusantibody IgG was 71.42％,66.67％,71.42％ and66.67％ respectively while those of IgM was 75.00％,44.44％,37.50％ and 80.00％ respectively.Conclusion BALF-GM and serum IgG are of great significance in the diagnosis of IPA in the elderly non-neutropenic patients,and their diagnostic values are superior to those of serum GM and IgM.关键词
支气管肺泡灌洗液/半乳甘露聚糖/抗体/诊断Key words
bronchoalveolar lavage fluid/galactomannan/antibody/diagnosis引用本文复制引用
任杰,焦洋,黄怡..支气管肺泡灌洗液半乳甘露聚糖诊断老年肺曲霉病的研究[J].老年医学与保健,2018,24(1):14-17,4.基金项目
国家重点研发计划重大慢性非传染性疾病防控研究重点专项(2017YFC1309704) （2017YFC1309704）
