老年医学与保健2018，Vol.24Issue(1)：18-21,4.
热量限制及隔日禁食对小鼠氧化应激水平的影响
Effects of Calorie Restriction and Alternate Day Fasting on Oxidative Stress in Mice
摘要
Abstract
Objective To observe the effect of caloric restriction and alternate day fasting on the levels of SOD,GSH-Px and MDA in 12-month-old male c57 mice.Methods 32 male c57 mice of 12 months old were randomly divided into 3 groups:control group (normal feeding),caloric restriction group (fed with 60％ of normal diet),alternate day fasting group;after 16 weeks,animal models were established;the livers of the mice in each group were taken to measure SOD activity,GSH activity and MDA content.Results The activities of SOD and GSH in caloric restriction group increased much higher while MDA dropped down lower than those in control group (P＜0.05);the activities of SOD and GSH in alternate day fasting group increased higher while MDA dropped down slightly lower than those in control group (P＜0.05);the activities of SOD and GSH in caloric restriction group increased slightly higher while MDA dropped down slightly lower than those in alternate day fasting group (P＜0.05).Conclusion To varying degrees,caloric restriction and alternate day fasting can improve the oxidative stress in mice at certain degree,caloric restriction is more effective in improving the oxidative stress balance in mice than alternate day fasting.关键词
热量限制/隔日禁食/氧化应激Key words
calorie restriction/alternate day fasting/oxidative stress引用本文复制引用
沈赟,钟远,苗雅..热量限制及隔日禁食对小鼠氧化应激水平的影响[J].老年医学与保健,2018,24(1):18-21,4.基金项目
国家自然基金项目(81300933) （81300933）
上海市科委基金项目(13JC401504) （13JC401504）
