老年医学与保健2018，Vol.24Issue(1)：26-29,4.
补肾益髓方治疗阿尔茨海默病的临床疗效观察
Clinical Effect of the Treatment with Bushenyisui Formula on Alzheimer's Disease
摘要
Abstract
Objective To observe the clinical effect of the treatment with Bushenyisui Formula on patients with Alzheimer's disease (AD).Methods A randomized,double-blinded,double-dummy,positive drug controlled trial was conducted;68 AD patients were divided into 2 groups:experiment group and control group,34 in each;the treatment with Bushenyisui Formula and donepezil analogue were applied to patients in experiment group while donepezil and the Bushenyisui Formula analogue were applied to patients in control group;mini-mental state examination (MMSE) was made on all the patients before treatment,24 weeks after treatment and 48 weeks after treatment,and the clinical effect was observed.Results 24 weeks after treatment,the total scores of MMSE,language ability,delayed memory,attention and calculation power of the patients in experiment group were much more improved than before treatment (P＜0.05),the same in control group except delayed memory (P＜0.05);the delayed memory of the patients in experiment group was superior to that of the patients in control group;there existed no statistical difference in total scores of MMSE and the scores of other subitems between the 2 groups;48 weeks after treatment,the total scores of MMSE,delayed memory,attention and calculation power of the patients in experiment group were more improved than before treatment (P＜0.05) while the total scores of MMSE and the scores of other subitems of the patients in control group were of no statistical difference from those before treatment;the total scores of MMSE in experiment group were superior to those in control group,the difference was of statistical significance (P＜0.05),and the difference in the scores of other subitems between the 2 groups was of no statistical significance.Conclusions The treatment with Bushenyisui Formula is of certain effect in improving the neurological function of AD patients.关键词
阿尔茨海默病/神经心理学测验/补肾益髓Key words
Alzheimer's disease/neuropsychological test/Bushenyisui Formula引用本文复制引用
黄凯,顾耘,韩素静,孙国珺..补肾益髓方治疗阿尔茨海默病的临床疗效观察[J].老年医学与保健,2018,24(1):26-29,4.基金项目
973计划中医理论专项子课题(2010CB530405) （2010CB530405）
