南京医科大学学报（自然科学版）2018，Vol.38Issue(1)：20-24,5.DOI:10.7655/NYDXBNS20180105
MR动态磁敏感对比增强灌注技术在胶质瘤复发和放射性脑损伤鉴别诊断中的价值
The value of dynamic susceptibility-weighted contrast-enhanced MR imaging in differentiating glioma recurrence and cerebral radiation injury
摘要
Abstract
Objective:To explore the value of dynamic susceptibility-weighted contrast-enhanced(DSC)MR imaging in differentiating glioma recurrence and cerebral radiation injury.Methods:Twenty-eight patients who had cerebral gliomas were treated with radiotherapy after operation, presenting newly abnormal enhancement.All the patients underwent routine MR, DSC perfusion.The value of rCBV and rCBF in the new enhanced lesion and the opposite white matter were measured and analyzed.Receiver operating characteristic (ROC) curve was used to find the best classification threshold, and then calculating its sensitivity, specificity and accuracy.Results:The relative rCBV and rCBF value in the recurrent lesion were 2.78 ± 1.01 and 1.89 ± 0.82, respectively, while in the radiation injured lesion were 0.76 ± 0.42 and 0.47 ± 0.31, respectively (all P ＜ 0.05).Analysis of ROC curve showed that:if the relative rCBV value≥1.88, the diagnosis specificity of recurrent glioma was 100.0％;if the relative rCBV value≤0.62, the diagnosis sensitivity of radiation injuries was 100.0％.The threshold of the relative rCBV value was 1.88, and the differential diagnosis sensibility, specificity,and accuracy were 94.4％, 100.0％ and 96.4％, respectively.If the relative rCBF value≥1.96, the diagnosis specificity of recurrent glioma was 100.0％;if the relative rCBF value≤0.45, the diagnosis sensitivity of radiation injuries was 100.0％.The threshold of the relative rCBF value was 0.85, and the differential diagnosis sensibility, specificity, and accuracy were 94.4％, 90.0％ and 92.8％,respectively.Conclusion:DSC MRI is helpful to differentiate glioma recurrence and cerebral radiation injury.关键词
胶质瘤/复发/放射性脑损伤/磁共振灌注加权成像/动态磁敏感对比增强Key words
gliomas/recurrence/cerebral radiation injury/magnetic resonance perfusion-weighted imaging/dynamic susceptibility contrast-enhanced分类
医药卫生引用本文复制引用
张军霞,王颖毅,王敏,王建伟,刘俊..MR动态磁敏感对比增强灌注技术在胶质瘤复发和放射性脑损伤鉴别诊断中的价值[J].南京医科大学学报（自然科学版）,2018,38(1):20-24,5.基金项目
国家自然科学基金(81302185) （81302185）
