南京医科大学学报（自然科学版）2018，Vol.38Issue(1)：88-91,98,5.DOI:10.7655/NYDXBNS20180120
宫颈癌术后静态调强放疗与容积旋转调强放疗的比较
Comparison of IMRT and VMAT strategies for postoperative cervical cancer patients
摘要
Abstract
Objective:The primary aim of this study was to compare the incidence of acute adverse reactions and dosimetric parameters of postoperative cervical cancer patients with intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT), and to provide the reasonable selection of the cervical cancer patients who had needed postoperative radiotherapy.Methods:In our study, a total of 100 cervical cancer patients who needed postoperative radiotherapy were respectively treated with IMRT or VMAT, including 50 patients in the IMRT group and 50 patients in the VMAT group.The acute radioactive adverse reactions,dose of organ at risk (OAR), homogeneity index (HI), conformity index (CI), the number of monitor units (MUs) and treatment times were compared between the two groups.Results:The incidence of acute radioactive enteritis in the VMAT group was obviously lower than the IMRT group (38％ vs.64％, P ＜ 0.05).Compared with the IMRT group, the incidence of upper gastrointestinal tract reaction significantly decreased in the VMAT group (20％ vs.6％, P ＜ 0.05).The small intestine V40 and rectum V40 of the VMAT group was markedly lower than those of the IMRT group (P ＜ 0.01).However, rectum and small intestine V20 and V30, as well as bladder V20,V30, and V40 showed no statistical difference between the two groups (P ＞ 0.05).Compared with the IMRT group, the CI of VMAT group was significantly improved (P ＜ 0.05), while there were no statistical differences of the HI between the two techniques (P ＞0.05).The MUs and treatment times of the VMAT group compared with those of the IMRT group were significantly decreased by 50％ and 54％, respectively (P ＜ 0.01).Conclusion:VMAT is superior to IMRT in many aspects.Cervical cancer postoperative patients choose VMAT treatment could reduce the acute radioactive adverse reactions, decrease the dose of OAR, and shorten the treatment time of radiotherapy to improve the tolerance of patients with postoperative radiotherapy.关键词
宫颈癌术后/放射治疗/静态调强放疗/容积旋转调强放疗Key words
postoperative cervical cancer patients/radiotherapy/IMRT/VMAT分类
医药卫生引用本文复制引用
朱必清,武雅琴,韩晶晶,李倩,徐寒子,陆谔梅..宫颈癌术后静态调强放疗与容积旋转调强放疗的比较[J].南京医科大学学报（自然科学版）,2018,38(1):88-91,98,5.基金项目
江苏省妇幼健康科研项目(F201762) （F201762）
