摘要
Abstract
Objective:To explore the effects of Shugan Jieyu decoction combined with nucleoside drug lamivu-dine on liver function,HBV-DNA and HBV-YMDD resistant mutants in patients with chronic hepatitis B. Methods:A total of 120 patients with chronic hepatitis B were randomly divided into the experiment group and the control group,60 cases in each group. On the basis of supportive treatment,the control group was treated with lamivudine,while the experiment group was given lamivudine combined with Shugan Jieyu de-coction. The liver function,the conversion rate of HBV-DNA,the mutation rate of HBV-YMDD and the clini-cal effect were observed and compared between the two groups of patients after the treatment for 6 and 12 months. Results:There was significant difference between the two groups on the liver function index such as alanine aminotransferase (ALT),aspartate transaminase (AST),total bilirubin (TBiL) and the mutation rate of HBV-YMDD at 2 time points(P<0.05). HBV-DNA conversed into negative in the experiment group more significantly than that in the control group 12 months after the treatment(P<0.05). The total effective rate in the experiment group was 83.33％,significantly higher than that in the control group with statistical differ-ence(P<0.05). Conclusion:Shugan Jieyu decoction combined with Lamivudine can effectively reduce the liver function index,improve the negative rate of HBV-DNA,and reduce the mutation rate of HBV-YMDD.关键词
疏肝解瘀汤/拉米夫定/慢性乙肝/HBV-DNA/HBV-YMDDKey words
Shugan Jieyu decoction/lamivudine/chronic hepatitis B/HBV-DNA/HBV-YMDD分类
医药卫生
