实用肝脏病杂志2018，Vol.21Issue(2)：261-264,4.DOI:10.3969/j.issn.1672-5069.2018.02.026
经肝动脉化疗栓塞联合射频消融术和艾迪治疗原发性肝癌患者疗效及其对外周血T淋巴细胞亚群的影响
Efficacy of transcatheter arterial chemoembolization combined with radiofrequency ablation and Addie injection in the treatment of patients with primary liver cancer
摘要
Abstract
Objective To investigate the efficacy of transcatheter arterial chemoembolization(TACE) combined with radiofrequency ablation(RFA)and Addie injection in the treatment of patients with primary liver cancer(PLC). Methods A total of 76 PLC patients were recruited in our hospital between January 2013 and January 2015,and they were divided into the observation group(n=36)and the control group(n=40),receiving combination of TACE,RFA and Addie and TACE and RFA,respectively. Serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6),and peripheral blood lymphocyte subsets were assayed. The quality of life was evaluated by Karnofsky's score. Results There were significant difference in the disease control rate between the observation and the control group(91.7% vs. 72.5%)at the end of 3 month after treatment(P<0.05);serum CRP,TNF-α and IL-6 levels were(109.8±13.2)mg/L,(0.5±0.2)pg/mL and(13.4± 2.2)pg/mL in the observation group,significantly lower than [(156.2±20.4)mg/L,(1.1±0.2)pg/mL and(24.1± 4.4)pg/mL in the control,P<0.05];the percentages of peripheral blood CD3+and CD4+cells and ratio of CD4+/CD8+cells were(60.1±9.7)%,(44.3±8.3)% and(1.9±0.5),respectively,significantly higher than [(52.2±9.9)%, (36.30 ±8.6)% and(1.4 ±0.3)in the control,P<0.05];the improvement rate of quality of life was significantly higher than that in the control group (80.5% vs. 57.5%,P<0.05);at the end of 24 month followed-up,28(77.8%)survived in the observation group,while 29(72.5%)survived in the control(P>0.05). Conclusions Addie injection,a herbal compound,might improve the quality of life in PLC patients receiving TACE and RFA therapy,which might be related to the reduction of inflammatory reaction,and enhance immune functions.关键词
原发性肝癌/肝动脉化疗栓塞术/射频消融/艾迪注射液/治疗Key words
Hepatoma/Transcatheter arterial chemoembolization/Radiofrequency ablation/Addie injection/a hebal compound/Therapy引用本文复制引用
刘大勇,杨光华,鲁朝敏..经肝动脉化疗栓塞联合射频消融术和艾迪治疗原发性肝癌患者疗效及其对外周血T淋巴细胞亚群的影响[J].实用肝脏病杂志,2018,21(2):261-264,4.基金项目
河南省自然科学研究计划项目(编号:201310471055) （编号:201310471055）
