摘要
Abstract
Objective To evaluate the efficacy of cytokine-induced killer(CIK),three-dimensional conformal radiotherapy(3D-CRT)and transcatheter arterial chemoembolization(TACE)in the treatment of patients with primary liver cancer(PLC). Methods 51 patients with PLC were randomly divided into combination group(n=26),receiving TACE/3D-CRT/CIK therapy,and control(n=25),receiving TACE/3D-CRT therapy. Results At the end of one month therapy,the percentage of CD3+,CD4+,CD16+CD56+and CD4+/CD8+ratio in the combination group were(66.47±1.25)%,(56.98±2.65)%,(22.45±6.41)% and(1.52 ±2.10),significantly higher than[(53.17± 0.98)%,(48.09±0.27)%,(19.74±1.88)% and(1.13±0.06),P<0.05],while that of CD8+cells was(37.56±1.26)%, much lower than [(42.67 ±4.35)%,P<0.05]in the control;the improvement rate of life quality in combination group was 84.6%,significantly higher than that in the control group(52.0%,P<0.05);the objective effective rate in the combination group was 92.3%,significantly higher than that in the control group(68.0%,P<0.05);the 1-year survival rate in the combination group was 73.1%,significantly higher than that in the control group(52.1%,P<0.05). Conclusion CIK cells combined radiotherapy and TACE for patients with PLC could improve the immune function,and patients' quality of life,which might lead to a good short-term efficacy and prolong the survival.关键词
肝肿瘤/肝动脉栓塞化疗/三维适形放疗/细胞因子诱导的杀伤细胞/治疗Key words
Hepatoma/Transcatheter arterial chemoembolization/Dimensional conformal radiotherapy/Cytokine-induced killer cells/Therapy
