实用肝脏病杂志2018，Vol.21Issue(2)：309-312,4.DOI:10.3969/j.issn.1672-5069.2018.02.046
葡萄糖调节蛋白78在非酒精性脂肪性肝病发病中的作用
Role of glucose regulated protein 78 in the pathogenesis of nonalcoholic fatty liver disease
摘要
Abstract
Glucose regulated protein 78(GRP78)is regarded as a major chaperone of endoplasmic reticulum(ER),which plays an important role in the process of protein folding and transport as well as endoplasmic reticulum stress. In addition,it also exists in the surface of tumor cells,endothelial cells and monocytes,and serves as a receptor for viral entry into host cells. ER stress is an important pathogenesis of nonalcoholic fatty liver disease(NAFLD). The excavation of GRP78's function will provide a new approach for the defense mechanism of NAFLD.关键词
非酒精性脂肪性肝病/葡萄糖调节蛋白78/内质网应激Key words
Nonalcoholic fatty liver disease/Glucose regulated protein 78/Endoplasmic reticulum stress引用本文复制引用
王兰..葡萄糖调节蛋白78在非酒精性脂肪性肝病发病中的作用[J].实用肝脏病杂志,2018,21(2):309-312,4.基金项目
浙江省医药卫生一般研究计划项目(编号:2014KYA079) （编号:2014KYA079）
