中国组织工程研究2018，Vol.22Issue(4)：625-630,6.DOI:10.3969/j.issn.2095-4344.0101
治疗骨质疏松和骨折何时联用或介入抗骨质疏松治疗
Application of anti-osteoporotic medications in osteoporotic fractures
倪梦杉 1陈贤哲 1陈宇雄 1郭文杰 1田京2
作者信息
- 1. 南方医科大学第二临床医学院,广东省广州市 510282
- 2. 南方医科大学珠江医院骨科中心,广东省广州市 510282
- 折叠
摘要
Abstract
BACKGROUND: Patients with osteoporosis are prone to develop fractures, and moreover some patients are first diagnosed with osteoporosis because of a fragility fracture. Therefore, it is critical to understand the correlation between osteoporotic medications and fracture healing. OBJECTIVE: To summarize the effect of anti-osteoporosis medications on osteoporotic fracture healing in order to promote its clinical application. METHODS: A computer-based online search of PubMed, CNKI, VIP and WanFang databases between January 2012 and July 2016 was performed to retrieve the related articles with the keywords of "osteoporotic fracture, healing, bone nutrition supplements, anti-resorptive agents, anabolic agents, dual effect agents, new targeted agents" in English and Chinese, respectively. Literature concerning the effect of anti-osteoporosis medications on fracture healing was selected, and the articles published lately in authoritative journals were preferred. RESULTS AND CONCLUSION: Most of anti-osteoporotic medications have no harmful influence on fracture healing, including bone nutrition supplements (calcium and vitamin D), anti-resorptive agents (bisphosphonate, denosumab, estrogen and selective estrogen receptor modulators, statins and calcitonin), anabolic agents (parathyroid hormone), and dual effect agents (strontium ranelate). Calcium and vitamin D are the basic drugs; anti-resorptive agents exert overt anti-osteoporotic effect; and the new targeted agents like cathepsin K inhibitor and sclerostin monoclonal antibody provide more choices for the therapy of osteoporotic fracture. Partial anti-osteoporotic agents inhibit the viability of osteoclasts, so their early application may be against fracture healing. The optimal time of anti-osteoporotic medications and the effect on acute and non-acute osteoporotic fractures need to be further explored.关键词
抗骨质疏松药物/组织构建/骨质疏松/骨折分类
医药卫生引用本文复制引用
倪梦杉,陈贤哲,陈宇雄,郭文杰,田京..治疗骨质疏松和骨折何时联用或介入抗骨质疏松治疗[J].中国组织工程研究,2018,22(4):625-630,6.
