中国组织工程研究2018，Vol.22Issue(5)：787-792,6.DOI:10.3969/j.issn.2095-4344.0452
干细胞修复宫腔粘连:初级阶段研究成果的转化意义
Stem cell repair of intrauterine adhesions: preliminary achievements and clinical translation
摘要
Abstract
BACKGROUND: Stem cells exhibit immeasurable application potentials in tissue and organ repair, but stem cell transplantation for the treatment of intrauterine adhesions is still in the initial stage. OBJECTIVE: To review the research progress in the stem cell repair of intrauterine adhesions. METHODS: We retrieved ISI Web of Science database, PubMed database and CNKI database for representative clinical research, basic research and reviews concerning stem cell therapy for intrauterine adhesions. The keywords were "intrauterine adhesion, metrosynizesis, Asherman's syndrome, stem cell, endometrial stem cell, stem cell transplantation" in English and Chinese, respectively. After repetitive studies were excluded, 43 articles were reviewed in the result analysis. RESULTS AND CONCLUSION: Hysteroscopic transcervical resection of adhesions is an ideal treatment for intrauterine adhesions, but the postoperative recurrence rate of intrauterine adhesions is still high. The human endometrium has high proliferative activity, and the endometrium of a woman of childbearing age may experience growth, differentiation and exfoliation for over 400 times, indicating the existence of endometrial stem cells.Endometrial stem cells have been isolated from the endometrium,successfully cultured in vitro and induced for directional differentiation. However, studies on endometrial stem cell transplantation for intrauterine adhesions are still in its infancy. Basic research on stem cells will facilitate its application to clinical practice.关键词
子宫内膜干细胞/宫腔粘连/子宫内膜再生/胚胎干细胞/骨髓干细胞/干细胞/细胞培养分类
医药卫生引用本文复制引用
占欣璐,周梦妮,谭布珍..干细胞修复宫腔粘连:初级阶段研究成果的转化意义[J].中国组织工程研究,2018,22(5):787-792,6.基金项目
江西省社发领域重点项目(2106BBG70218) （2106BBG70218）
南昌大学研究生创新专项资金(cx2016338)the Social Development Project of Jiangxi Province,No.2106BBG70218 （cx2016338）
the Innovative Foundation for Postgraduates in Nanchang University,No.cx2016338 （）
