畜牧兽医学报2017，Vol.48Issue(11)：2005-2014,10.DOI:10.11843/j.issn.0366-6964.2017.11.001
骨骼肌卫星细胞增殖与成肌分化过程中关键信号通路的作用
The Role of Key Signaling Pathways in the Proliferation and Differentiation of Skeletal Muscle Satellite Cells
摘要
Abstract
Skeletal muscle satellite cells are considered to be the only stem cell source of adult skeletal muscle cells differentiation.It is generally in resting state.After stimulated,skeletal muscle satellite cells can be activated,proliferation and differentiation into muscle cells through the key signaling pathway,then participate in the formation of skeletal muscle and injury repair.Signaling pathways commonly involve in the process of proliferation and differentiation of skeletal muscle satellite cells.Such as Wnt and mTOR signaling pathways regulate satellite cell activity through cascade amplification,Notch and P38 MAPK signaling pathways are thought to be closely related to the resting state of satellite cells,JAK/STAT signaling pathway can cause different specific responses of satellite cells at different stages.These signaling pathways are linked to each other,and thus affect the growth and repair capacity of skeletal muscle satellite cells.In this paper,we reviewed the study progress of the effects of Wnt,Notch,P38 MAPK,mTOR,JAK/STAT signaling pathways on the proliferation and differentiation of skeletal muscle satellite cells,and laid a foundation for further study on the molecular mechanism of skeletal muscle formation and muscular development.关键词
骨骼肌/卫星细胞/信号通路/细胞增殖与分化Key words
skeletal muscle/satellite cells/signaling pathways/cell proliferation and differentiation分类
农业科技引用本文复制引用
郑琪,睢梦华,凌英会..骨骼肌卫星细胞增殖与成肌分化过程中关键信号通路的作用[J].畜牧兽医学报,2017,48(11):2005-2014,10.基金项目
安徽省自然科学基金(1708085MC61) （1708085MC61）
安徽省高校自然科学重点研究项目(KJ2017A334) （KJ2017A334）
