畜牧兽医学报2017，Vol.48Issue(11)：2015-2022,8.DOI:10.11843/j.issn.0366-6964.2017.11.002
重组鸭肠炎病毒载体疫苗研究进展
Progress of Recombinant Duck Enteritis Virus-vectored Vaccines
摘要
Abstract
Recombinant virus-vectored vaccine is a newly developed vaccine based on viral vectors delivering protective antigens of other pathogens.It can infect host cells and deliver antigen protein encoded by exogenous genes,stimulating both humoral and cellular immune responses.Duck enteritis virus (DEV) has a large genome about 160 kb in length,containing large amounts of non-encoding region and nonessential replication region.Recombinant genetic engineering techniques have brought forward a leap in molecular biology study of DEV and designing DEV-vectored vaccines.Recent studies have demonstrated that DEV may be a promising viral vector candidate and plays a crucial role in future vaccine development.In this review,we summarized the advances of studies on recombinant DEV-vectored vaccines to provide some valuable fundamental information for future DEV vaccine development.关键词
重组载体疫苗/鸭肠炎病毒/基因修饰/免疫/外源基因Key words
recombinant vectored-vaccine/duck enteritis virus/gene modification/immune/exogenous gene分类
农业科技引用本文复制引用
马云潮,程安春,汪铭书,吴英..重组鸭肠炎病毒载体疫苗研究进展[J].畜牧兽医学报,2017,48(11):2015-2022,8.基金项目
“十二五”国家科技支撑计划(2015BAD12B05) （2015BAD12B05）
国家现代农业(水禽)产业技术体系专项(CARS-43-8) （水禽）
四川省重点实验室专项(2016JPT0004) （2016JPT0004）
